168 ^'E\V YORK ZOOl.OGICAL SOCIETY. 



and extravasations of red cells into the sjilenic ])uli) are present, 

 in greater or less degree, throughout the entire tissue. I'.xten- 

 sive destrneticn of these cells is taking ])lace and pigmentation 

 resulting from this disintegration is general throughout. The 

 Malpighian bodies in this species appear to be ver}- small, but in 

 places tliey have been encroached upon by a chronic perarteritis. 



Bone. — Shaft of Feiiiur. The marrow is completely re])laced 

 by a dense mass of cells, among which nn)n(inuclears and epithe- 

 liod cells appear most frecpiently. l'ol\ nuclear leucocytes, fibro- 

 blasts single and multinucleated giant cells are also frequent. 

 Normoblasts are found in Init relatively small luuuber and exten- 

 sive destruction of blood cells appears to be taking i)lac(.'. as evi- 

 denced b\- the presence of ])hagocytic endotheliod cells, the cvto- 

 ])lasm of wliich is literall\- crammed witli brol^en down reil cells. 

 The endostium is intact in most places, but in other areas is largely 

 replaced by groujjs of osteoclasts which are evidently causing ab- 

 sor])tion of the adjacent com])act tissue. The 1 laversian canals 

 of the com])act bone are surrounded b\' broad zones of homo- 

 geneous osteoid tissue which is limited from the compact bone 

 by a fibrous band resembling endostium. Mxtravasation of red 

 blood cells into this tissue is present in ])laces. but in other areas 

 it is strictly osteoid in character, though, as a rule, the Haversian 

 vessels in the larger areas are surrotmded bv cellular tissue resem- 

 bling that of the marrow. A few of these spaces show an ap]iar- 

 ent cartilaginous formation resulting in rejilaceuK'nt of the vessels 

 and normal tissue. Xot infr(.-(|uentl\- the blood vi'ssc'ls a])i)ear to 

 be i)lugge(l 1)\- hw'dinr throml)i. 



CONCLUSION. 



We by no means consider this presentation of osteomalacia, as 

 it occurs in the Primates, conclusive or final. The question is of 

 the greatest ])ossible importance to Zoological societies, and until 

 some definite means of prevention can be devised, the subject can 

 be looked upon as little more than o])ened. It is. therefore, our ])ur- 

 ]iose in the future to study particidarly the genesis of the disease 

 and its treatment. For this reason it is first im])erative that 

 an es])ecially careful study of tin- urine in the m;ilad\ be madi'. 

 particularly as to its increa>e in t-oiUeiit of boui' sall^ and ;is to 



the presence or ab.sence of lactic acid in both urine and bl 1. We 



also j)ropose to thoroughly investigatt' the condition as alf\-ctc-d 

 by the administration of the extracts of tlu' ductless glands, nota- 

 bl\- those of the tlnroid and adrenal. 



