528 PRACTICE OF PHYSIC. 



had the effect of inducing sleep, it was manifestly with advan- 

 tage. At the same time, in some cases, from doubts whether 

 the disease might not depend upon some organic lesions of the 

 brain, when the opium would be superfluous ; and in other cases, 

 from doubts whether there might not be some inflammatory affec- 

 tion joined with the mania, when the opium would be hurtful ; 

 I have never pushed this remedy to the extent that might be 

 necessary to make an entire cure. " I have gone the length of 

 giving five grains of opium in persons hardly accustomed to the 

 remedy, and in several cases with good effects. 11 



MDLXXII. Camphire has been recommended as a remedy 

 of mania, and there are instances alleged of its having perform- 

 ed an entire cure. As it appears from the experiments of 

 Beccaria, that this substance is possessed of a sedative and 

 narcotic virtue, these cures are not altogether improbable ; but 

 in several trials, and even in large doses, I have found no ben- 

 efit from it ; and excepting those in the Philosophical Trans- 

 actions, No. 400., I have hardly met with any other testimonies 

 in its favour. 



MDLXXIII. I have been informed that some maniacs 

 have been cured by being compelled to constant and even hard 

 labour ; and, as a forced attention to the conduct of any bodily 

 exercise is a very certain means of diverting the mind from 

 pursuing any train of thought, it is highly probable that such 

 exercise may be useful in many cases of mania. 



I must conclude this subject with observing, that even in 

 several cases of complete mania, I have known a cure take 

 place in the course of a journey carried on for some length 

 of time. 



MDLXXIV. These are the remedies which have been 

 chiefly employed in the mania that has been above described ; 

 and I believe they have been employed promiscuously, without 

 supposing that the mania was to be distinguished into differ- 

 ent species. Indeed, I am not ready to say how far it is to be 

 so distinguished ; but I shall offer one observation which may 

 possibly merit attention. 



It appears to me, that there are two different cases of mania 

 that are especially different, according to the original tempera- 

 ment of the persons whom the disease affects. It perhaps oc- 



1 



