TERMINATIONS OF INFLAMMATION. 11 



ever, are not renewed : a substance unlike to the lost texture 

 unites the divided surfaces, but it has neither the aspect, 

 the sensibilities, or functions of that the place of which it 

 supplies. Skin is one of those parts never regenerated ; 

 the place covered is ever afterwards not only conspicuous to 

 the common observer — and hence has got the name of a 

 cicatrix, or scar — but is also apparent to the anatomist, who 

 discovers that, from a deficiency of cellular tissue beneath 

 the scar, the cicatrix is tightly and immovably bound down ; 

 he also notes that, in consequence thereof, he cannot make 

 the same clean and facile separation of parts which he has 

 made elsewhere. Added to which, if we compare the new skin 

 closely with the old, we shall find manifest differences in their 

 organization. The same observation applies to mucous and 

 serous membranes : both are never regenerated after losses, 

 for, in either instance, the new-formed structure will bear no 

 comparison with the original formation ; the cicatrix after a 

 time turns white, from possessing a lower degree of vascu- 

 larity than the surrounding parts, and often exhibits a 

 puckered aspect. Neither the cuticular papillae nor the 

 mucous follicles are discoverable in the cicatrix. Bone 

 seems to be a substance reproducible with peculiar facility ; 

 indeed, there is in the horse a remarkable disposition to 

 take on what is called the ossific inflammation : cartilage, 

 ligament, and tendon are of this character; blood-vessels 

 occasionally become osseous ; and even the heart itself has 

 been found partially changed into bone. To these may be 

 added the muscular and nervous structures, both of which 

 appear to be united by some new formed substance, but 

 neither of which seems susceptible of regeneration. After 

 the operation of neurotomy, the divided extremities of the 

 nerve unite ; the uniting cord, however, is found to consist of 

 fibro-cellular material different altogether from the pulp of 

 the original nerve, having commonly a little knot or pro- 

 tuberance about its middle. Breaches in muscles are re- 

 paired by a cellular substance differing from muscular fibre, 

 yet serving to connect the divided parts, but never re- 

 storing their function of contractility. 



