202 CAUSES OF GLANDERS. 



the borders of whose nostrils, and upon the sides of the necks, the 

 virus of glanders had been inserted, almost all had, where punctures 

 had been made around their noses, spreading ulcerations, preceded 

 by a good deal of tumefaction of the parts, and accompanied by 

 some swelling of the submaxillary lymphatic glands. 



" Fifthly : that a mule, three asses, and an ass foal, into whose 

 submaxillary intervals wounds were made, in which were insinu- 

 ated, and by suture maintained, lymphatic glands, excised from 

 the same parts in glandered horses, not one of them experienced 

 any symptom of glanders ; but the young ass died on the sixth 

 day, from a large submaxillary ulceration, and consequent tume- 

 faction of the parts about the throat, which ended in every 

 symptom of suffocation. 



" Sixthly : that of two horses, a mare, a mule, and two asses, 

 into the jugular veins of each of which he injected from a kilogram 

 and a half to three kilograms of blood, drawn from either the ju- 

 gulars or carotids of glandered horses, not one became affected with 

 glanders ; though they all died from the first to the fifth day after 

 transfusion." 



" One might object, that, as most of these experiments were 

 made on aged animals, or such as were worked down in condition, 

 or reduced from bad feeding, &c., the deductions from them 

 were not equally valid with what they would have been, had the 

 subjects been young, and in the enjoyment of their full strength. 

 There is some foundation, no doubt, for such objections; but for 

 such experiments we had no other subjects than such as were pur- 

 chased by the pupils for dissection; and out of them I made 

 choice of those in best condition, and such as were free from any 

 malady. And further, all such as were selected were, while under 

 experiment, well fed, it being an object to prolong their life to the 

 period desired. 



" Neither colour nor sex appeared to have any influence in these 

 experiments. And in all the subjects that became glandered, the 

 discharge has been nearly the same from both nostrils, with this 

 difference, that it almost always appeared, as well as the tumefac- 

 tion of the glands and the chancres, somewhat earlier on the left 

 than on the right side of the head. 



