CAUSES OF GLANDERS. 209 



transfusing more blood than was requisite, the ass appeared puifed 

 out or swollen in every part of its body : the tumefaction was, 

 however, relieved in four or five days, in the course of which time 

 the animal became glandered in a most virulent degree ; and to 

 prove that his disease really was glanders, other asses were inocu- 

 lated from this one, and they all, without a single exception, shared 

 the same fate. The blood lost by the horse was not sufficient to 

 deprive him of vitality*." 



Smith, 1818, as a non-contagionist, stands in the same rank 

 with Dupuy and Coleman. ''Having been taught," he says, *'at 

 a very early period of life, to believe that glanders is a disease 

 highly infectious, and holding my preceptor (this could not be 

 Coleman) in great estimation, I received his opinions on the sub- 

 ject with implicit confidence." Farther, Mr. Smith states in his 

 preface, that, in offering the result of his experience, he has '•' no 

 wish to allure any into fatal security, by inducing them to permit 

 the diseased subject to remain with one that is perfectly free from 

 it." — The " causes of glanders" Mr. Smith enumerates to be, — 

 I. General debility. — II. A previous disease. — III. 

 Breathing an impure air. — IV. Exposure to a current 



OF COLD AIR, OR BEING PERMITTED TO DRINK COLD WATER 

 WHEN HOT. — V. A SUDDEN TRANSITION FROM COLD TO HEAT, 



and VICE VERSA. — VI. Infection. The first three of these 

 Mr. Smith regards as PREDISPOSING CAUSES; the latter three 

 being EXCITING CAUSES. " General debility may be considered 

 as the forerunner of every disease, the system being thereby ren- 

 dered more susceptible to morbid impressions." '* Glanders is fre- 

 quently produced by a variety of other diseases." — ''• I have seen 

 the mucous membrane ulcerated, the bone carious, and all the 

 characteristic symptoms of glanders produced by the cut of a sabre. 

 I have also seen one case in which glanders was produced from 



* " No proofs can be more conckisive than those which the Professor 

 (Coleman) adduces of the contagious poison in question affecting the mass 

 of blood, and producing ill effects through this medium, viz. the production 

 of the disease in one animal by the inoculation with the matter of secretion, 

 and in another by tranfusion into its veins of the fluid from which such secre- 

 tion is formed." — Travers Inquiry concerning Constitutional Irritation. 



