263 SEAT AND NATURE OF GLANDERS. 



Disease, common]y caWed glanders, consumption, strangles, farcy, 

 8jc., I was the first to introduce to the notice of my brother vete- 

 rinarians in this country, occupies one of the highest stations in our 

 present historical catalogue, as being the author of an entire new 

 doctrine on the patliology of glanders, farcy, &c. Holding in little 

 estimation the opinions of his predecessors ; looking upon them as 

 altogether insufficient to account for the phenomena exhibited in 

 glanders and farcy, and resolved, if possible, to discover 'Uhe 

 source of the evil," he traced the origin of both these diseases, as 

 Avell as that of several others, not of horses only, but of dogs, cats, 

 monkeys, and domestic fowls as well, to the existence and develop- 

 ment of tubercle in some part or other of the body, and, accordingly, 

 he ranged all these several disorders of the animals mentioned 

 mider the generic appellation of "TUBERCULOUS AFFECTION." 



" Tubercles, which appear as little, firm, grey, hard bodies, are 

 organic productions, originating from causes unknown, existing at 

 first in small numbers, and interfering but little with the functions 

 of the parts generating them. In this, their incipient state, the 

 animal enjoys perfect health, and continues in the preservation of it 

 up to the period of the disorganization of the tubercle, those changes 

 in its interior which end in its mortification and ulceration. In tim.e, 

 they increase in number, and the result is a discharge commonly 

 from one nostril, which, at its commencement, is regarded as catarrh 

 or strangles. This stage may occupy a term of five or six years*. 

 In the second stage the tubercles grow soft, break, and become con- 

 verted into ulcers. There are varieties of tubercles; the most 

 common are the miliary ; and these are the precursors of that 

 species of ulceration which I have described (at page 169) as re- 

 sembling worm-eaten wood. They are found in greatest numbers 

 in the course of the large veins upon the septum. They are 

 also found within the duplicature of the ala nasi, and upon the 

 turbinated bones, pursuing the course of the large bloodvessels. 

 They may even exist within the substance of the cartilage of the 

 septum, and thus assist in its destruction. The membrane lining 



* Dupuy cannot exactly say how long : once developed, however, resolution 

 ib hopeless. 



