SEAT AND NATUIIK OV GLANDERS. 281 



into question. Indeed, at the present day even, we have only to 

 give a little more scope to Lafosse's definition still to confirm its 

 truth, and say, that 



The Seat of Glanders — instead of being confined to ike 

 jntuiiary membrane — is in THE AERIAL MEMBRANE* ; that mem- 

 brane with which the respired air comes into contact, and which 

 constitutes the lining of the nose, of the sinuses of the head, of the 

 windpipe and its ramifications. Dupuy, in investigating the seat 

 of the tuberculous affection, so far as he found it corresponded to 

 our glanders, came to the conclusion, that, commonly, the disease 

 attacked, iirimarily, " the mucous membrane lining the frontal, 

 maxillary, and other sinuses ; secondly, and next most frequently, 

 "the membrane lining the chambers of the nose ;" thirdly, "the 

 lungs." Rodet, the adopter and expounder of Dupuy's doctrines, 

 tells us that the pituitary or Schneiderian membrane may become 

 secondarily affected, " through extension of the disease from the 

 hmgs." 



The earliest intimation we receive of disease in the aerial 

 membrane consists in discharge from the nose, which may either 

 be speedily followed by ulceration, or may continue for an indefi- 

 nite length of time with but trifling alterations of it either in 

 quality or quantity. Of the primary morbid changes in the mem- 

 brane — unless the disease should happen to attack the part cover- 

 ing the septum nasi — we can obtain no information : injection of its 

 vessels, amounting or not to inflammation, may exist hours, or even 

 days, before any running from the nose appears of that quantity or 

 quality to attract notice : the submaxillary gland in the meanwhile 

 becoming swollen or not, according to .the amount of local irritation 

 present. The case at the beginning will assume that insidious or 

 indefinite form that it may, and particularly when no suspicion 

 lurks in the mind of the examiner, be mistaken for catarrh, the in- 

 flammatory or augmented vascular action in the membrane, of the 

 frontal and other sinuses, proceeding all the while, converting the 

 natural scanty mucous secretion into a copious and morbid or ma- 



* This appellation is preferred on account of its comprehensiveness. Had 

 we said tlie membrane lining the air-passages, the sinuses of the head might 

 appear not to have been included. 



