282 SEAT AND NATURE OF GLANDERS. 



lignant one, and increasing through infiltration and interstitial de- 

 * posit materially the thickness or substance of the membrane. 

 These are the primary, in some instances the only, changes the 

 aerial membrane undergoes in glanders; and though they are 

 alterations which would take place from any common irritation 

 and inflammation, still, in the case of glanders, they must be re- 

 garded as specific ones, from the circumstances of the discharges 

 (from the nose) being found capable, through inoculation, of en- 

 gendering similar disease in another (equine or human) animal. 

 Vascular injection and thickening are succeeded by the appearance 

 of pimply or tubercular elevations upon the surface of the mem- 

 brane ; and these, as we have already seen, are but the preludes of 

 a correspondent number of ulcerations, called chancres, in which, 

 for the first time, supposing them to be visible, we may distinguish 

 characters such as are peculiar to glanderous disease; or, at all 

 events, such are not seen in the ulcer which we meet with on the 

 occasion of common irritation or lesion from injury, whenever this 

 — rare though the occurrence be — does happen to take place. And 

 it is worthy of our especial remark, that the pimples or tubercles 

 make their appearance in waving lines, pursuing the courses of the 

 larger bloodvessels, the superficial veins in particular, the chan- 

 cres resulting from these pustular formations preserving the same 

 chain of connexion ; though, when the latter come to spread over 

 the surface of the membrane, these lines of concatenation are, in 

 course, rendered much less distinguishable. 



Notwithstanding every part of the aerial membrane is liable to 

 be, and, indeed, in its turn, has been known to be, the seat of glan- 

 ders, yet are certain parts of it much more frequently affected than 

 others, and, under a state of disease, present phenomena somewhat 

 different from what the other exhibit. Coleman's notion concern- 

 in"" the most frequent or especial seat of the disease corresponded 

 with Lafosse's : he thought the membrane clothing the septum nasi 

 was the part commonly attacked — that it possessed a peculiar or 

 especial susceptibility to be affected by the virus or miasm. Du- 

 puy, however, has found the sinuses of the head to be the primary 

 and most frequent place of attack ; and, knowing the subacute and 

 insidious form glanders in so many instances at its beginning as- 



