62 PHYSIC 



to subsequent mal- or non-assimilation and complete struc- 

 tural and functional breakdown. 



We thus see that the central nervous system determines 

 the incidence and particular local manifestations of a wide 

 range of disease, spreading over both aspects of distri- 

 bution, sensory or cutaneous, and motor or muscular, and 

 that the full recognition of this etiological principle, as a 

 diagnostic assistance, should always be taken advantage 

 of, as well as its use in affording indications of treatment. 



Moreover, many other allied diseases owe their origin 

 to the spread from the muscular terminations or attach- 

 ments to the bones of morbid materials and agencies, 

 which have already done their best and their worst during 

 their neuro-muscular transit, such as periostitis, ostitis, 

 abscesses, acute and cold, joint disease, perversion, and 

 destruction of skeletal developments, et hoc genus omne 

 all of which circumstances are inseparable from the great 

 laws of neuro-cutaneous and neuro-musculo-osseous evo- 

 lution and nutrition, and the origin in the great cerebro- 

 spinal cavity, and its contents, of a host of etiological 

 factors, which, let loose on the dependent structural ele- 

 ments, progress and eventuate on the lines of histological 

 continuity and materio-dynamic affinities, with the common 

 end of leaving in their track the history of structural 

 impairment and functional curtailment to mark the various 

 forms of morbid evolution proceeding from this little 

 suspected region of " cause and effect." 



