CONTENTS vii 



SECTION 



rri i 



5. Tnmethyl-histidine . _ 45 



6. Ergothioneine (Thiolhistidine Betaine) 46 



7. Hypaphorine (Trimethyl-tryptophane) - - - - 47 



8. Trigonelline (Methylnicotinic Acid) .... 47 



9. Other Pyridine Bases .... 48 



10. y-n-Butyrobetaine - .... 49 



11. Carnitine (Novaine, a-Hydroxy-y-butyrobetaine) - 50 



12. Myokynine - ... 52 



CHAPTER IV. 



CHOLINE AND ALLIED SUBSTANCES 53 



SECTION 



1. Choline- - - 54 



2. Amino-ethyl Alcohol (Colamine) and the Origin of Choline ; 



the possible Presence of other Bases in Phosphatides - - 58 



3. Neurine- ... 60 



4. Physiological Action of Choline and of Neurine - - - 61 



5. Natural and Synthetic Muscarines and their Physiological 



Action ----- 64 



6. Trimethylamine Oxide - - - 67 



7. Neosine 68 



CHAPTER V. 



CREATINE, CREATININE, GLYCOCYAMINE AND GUANIDINES - - 69 



SECTION 



1. Creatine and Creatinine - - - - 69 



2. Physiology of Creatine and Creatinine - - 71 



a. Distribution *- . - . . 71 



b. Metabolism - - - - - 73 



c. Possible Precursors of Creatine - - - - .77 



3. Glycocyamine and Glycocyamidine 78 



4. Guanidine - . 79 



5. Methylguanidine - 79 



6. as-Dimethylguanidine - - ... 80 



CHAPTER VI. 



ADRENALINE - - - . - 81 



SECTION 



1. Historical - - - - 81 



2. Nomenclature and Synonyms - - - 83 



3. Preparation and Purification of Natural Adrenaline - - 84 



4. Syntheses of Adrenaline - ... 85 



5. Adrenaline Substitutes - ... 87 



6. Physical and Chemical Properties of Adrenaline. Salts and 



Derivatives. Constitution - ... 87 



7. Colour Reactions of Adrenaline and Colorimetric Estimation 89 



8. Amount of Adrenaline in the Suprarenal Gland ; Yield ; 



Distribution in other Organs ; Origin - - - 92 



