536 BUKEAU OF ANIMAL INDUSTRY. 



(log, and in many unfortunate cases the virus spreads from the point 

 of inoculation to the entire sj'stem and destroys the wretched mortal 

 by extensive ulcers of the face and hemorrhage or by destruction of the 

 lung tissue; in other cases, however, glanders may develop, as in the 

 dog, in local form onl}^ not infecting the constitution and terminat- 

 ing in recovery, while the specific ulcer by proper treatment is turned 

 into a simple one. In the feline species glanders is more destructive 

 than in the dog. The point of inoculation ulcerates rapidly and the 

 entire S3''stem becomes infected. 



While a student the writer saw a lion in the service of Professor 

 Trasbot, at Alfort, which had contracted the disease by eating glan- 

 dcred meat and died with the lung riddled with nodules.* A litter of 

 kittens lapped the blood from the lungs of a glandcred horse on which 

 an autops}^ was being made, and in four days almost their entire faces, 

 including the nasal bones, were eaten away by rapid ulceration. Nod- 

 ules were found in the lungs. A pack of wolves in the Philadelphia 

 Zoological Garden died in ten days after being fed with the meat of a 

 glandercd horse. The rabbit, guinea pig, and mice are specially sus- 

 ceptible to the inoculation of glanders, and these animals are conven- 

 ient witnesses and proofs of the existence of suspected cases of the 

 glanders in other animals by the resiilts of successful inoculations. 



The primary lesions in any form is a local point in which occurs 

 a rapid proliferation of the cell elements which make up the animal 

 tissue with formation of new connective tissue, with a crowding- 

 together of the elements until their own pressure on each other 

 cuts off the circulation and nutrition, and death takes place in them in 

 the form of ulceration or gangrene. Following this primary lesion 

 we have an extension of infection by means of the spread of the bacilli 

 into those tissues immediately surrounding the first infected spot, 

 which are most suitable for the development of simple inflammatory 

 phenomena or the specific virus. The primaly symptoms are the result 

 of specific reaction at the point of inoculation, but at a later time the 

 virus is carried by means of the blood vessels and lymphatic vessels to 

 other parts of the body and becomes lodged at different places and 

 develops in them; again, when the disease has existed in the latent 

 form in the lungs of the animal and the virus is wakened into action 

 from any cause, we have it carried to various parts of the body and 

 developing in the most susceptible regions or organs. The points of 

 development are most frequently determined by the activity of the 

 circulation and the effects of exterior irritants. For example, if a 

 horse which has been so slightly affected with the virus of glanders that 

 no symptoms are visible is exposed to cold, rain, or sleet, or by the 

 rubbing of the harness on the body and the irritation of mud on the 

 legs, the disease is apt to develop on the exterior in the form of farcy, 

 while a full-blooded horse which is employed at speed and has its 



