= 



CHAP, i.] BLOOD. 17 



Putting these facts together, it is very clear that the pheno- 

 mena of the clotting of blood are caused by the appearance in the 

 plasma of fine fibrils of fibrin. So long as these are scanty, the 

 blood is simply viscid. When they become sufficiently numerous, 

 they give the blood the firmness of a jelly. Soon after their 

 formation they begin to shrink, and while shrinking enclose in 

 their meshes the corpuscles but squeeze out the fluid parts of the 

 blood. Hence the appearance of the shrunken coloured clot and 

 the colourless serum. 



15. Fibrin, whether obtained by whipping freshly-shed 

 blood, or by washing either a normal clot, or a clot obtained from 

 colourless plasma, exhibits the same general characters. It belongs 

 that class of complex unstable nitrogenous bodies called proteids 

 which form a large portion of all living bodies and an essential 

 part of all living structures. 



Our knowledge of proteids is at present too imperfect, and 

 probably none of them have yet been prepared in adequate purity, 

 to justify us in attempting to assign to them any definite formula ; 

 but it is important to remember their general composition. 100 

 parts of a proteid contain rather more than 50 parts of carbon, 

 rather more than 15 of nitrogen, about 7 of hydrogen, and rather 

 more than 20 of oxygen ; that is to say they contain about half 

 their weight of carbon, and only about ^th their weight of 

 nitrogen ; and yet as Ave shall see they are eminently the nitro- 

 genous substances of the body. They usually contain a small 

 quantity (1 or 2 p.c.) of sulphur, and many also have some 

 phosphorus attached to them in some way or other. When burnt 

 they leave a variable quantity of ash, consisting of inorganic salts 

 of which the bases are chiefly sodium and potassium and the acids 

 chiefly hydrochloric, sulphuric, phosphoric and carbonic. 



They all give certain reactions, by which their presence may 

 be recognised : of these the most characteristic are the following. 

 Boiled with nitric acid they give a yellow colour, which deepens 

 into orange upon the addition of ammonia. This is called the 

 xanthoproteic test ; the colour is due to a product of decom- 

 position. Boiled with the mixture of mercuric and mercurous 

 nitrates known as Milloris reagent they give a pink colour. 

 Mixed with a strong solution of sodic hydrate they give on the 

 addition of a drop or two of a very weak solution of cupric sul- 

 phate a violet colour which deepens on heating. These are arti- 

 ficial reactions, not throwing much if any light on the constitu- 

 tion of proteids ; but they are useful as practical tests enabling us 

 to detect the presence of proteids. 



The several members of the proteid group are at present dis- 

 tinguished from each other chiefly by their respective solubilities, 

 especially in various saline solutions. Fibrin is one of the least 

 soluble ; it is insoluble in water, almost insoluble in dilute neutral 

 saline solutions, and very sparingly soluble in more concentrated 



F. 2 



