1884—1885 175 



10th, his voice became rabietic, and his master, who had 

 heard the bark of a rabid dog twenty years ago, was seized 

 with terror, and brought the dog to M. Bourrel, who found that 

 he wa*; indeed in the biting stage of rabies. Fortunately a 

 lingering fidelity had prevented him from attacking his 

 master. . . . 



" This morning the rabic condition is beginning to appear 

 on one of the new dogs trephined on June 1, at the same time 

 as two refractory dogs. Let us hope that the other new dog 

 will also develop it and that the two refractory ones will 

 resist." 



At the same time that the Commission examined this dog 

 which developed rabies within the exact time indicated by 

 Pasteur, the two rabbits on whom inoculation had been per- 

 formed at the same time were found to present the first 

 symptoms of rabic paralysis. " This paralysis," noted Bouley, 

 is revealed by great weakness of the limbs, particularly of 

 the hind quarters ; the least shock knocks them over and 

 they experience great difficulty in getting up again." The 

 second new dog on whom inoculation had been performed 

 on June 1 was now also rabid ; the refractory dogs were in 

 perfect health. 



During the whole of June, Pasteur found time to keep his 

 daughter and son-in-law informed of the progress of events. 

 "Keep my letters," he wrote, "they are almost like copies 

 of the notes taken on the experiments." 



Towards the end of the month, dozens of dogs were sub- 

 mitted to control-experiments which were continued until 

 August. The dogs which Pasteur declared to be refractory 

 underwent all the various tests made with rabic virus; bites, 

 injections into the veins, trephining, everything was tried 

 before Pasteur would decide to call them vaccinated. On 

 June 17, Bourrel sent word that the new dog bitten on June 3 

 was becoming rabic ; the members of the Commission went to 

 the Bue Fontaine-au-Boi. The period of incubation had only 

 lasted fourteen days, a fact attributed by Bouley to the bites 

 having been chiefly about the head. The dog was destroying 

 his kennel and biting his chain ferociously. More new dogs 

 developed rabies the following days. Nineteen new dogs had 

 been experimented upon : three died out of six bitten by a 

 rabid dog, six out of eight after intravenous inoculation, and 

 five out of five after subdural inoculation. Bouley thought that 



