10 



MASS. EXPERIMENT STATION BULLETIN 308 



Figure 5. Lymphocyloma of fhe Ovary. The pathological cells show as black spots in the 

 photograph, i Magnified 420 diameters.) 



Neurolymphomatosis Complicated by Lymphocytomatosis 



The hepat'c, splenic, renal, ovarian, gastric, and small nerves were rarely 

 affected unless neuroh'mphomatosis was complicated b\- hmphoc\tomatosis. 

 Of the large nerves, the celiac plexus was most commonh- involved with neuro- 

 lymphoma as the ovary in the same bird was affected with h"mphoc>tonia. The 

 vagus, sciatic, and brachial ner\es were affected by neurohniphomas which had 

 apparenth' spread either by metastasis or direct infiltration to muscles of the legs, 

 wings, thymus and th\'roid glands, and visceral organs. Small l\mphoc\ tomas 

 were found embedded in the skin or located in the subcutis immediateU' under 

 it in 19 of the birds. The tumors were easily felt on palpation as irregular nodular 

 masses. Some of these tumors were located on the breast and exposed to irritation 

 when the birds were on the roosts, but ulceration was not found in any of them. 



Representative tumors were studied histologicalK- to see if the nerves supplying 

 the skin were involved also, and the\' apparenth were for all tissues within the 

 infiltrated areas had been converted into tumor cells. 



NeuroKmphomatosis was complicated with l\niphoc>tomatosis in Flocks 

 A, H, C. and D and the results appear in Table 3. No complications of neuro- 

 lymphomatosis and Kmphocxtomatosis occurred in Flocks E, F, and G and the 

 results of the studies of these flocks appear in Tables 1 and 2. 



Table 3 shows that in Flock A neurohmphomas were confined largeh- to 

 the celiac plexus and ovarian nerve, and the lymphoc\"tomas to the ovar\ . In 

 Flock B the neuroh nijihc mas were found mosth' in the vagus nerv'es while the 

 greatest number of lymphoc\ tomas appeared in the thyroid glands, the thymus 

 glands, li\er, spleen, and skin. In I'lock C the neurohmphomas occurred mostly 

 in the celiac plexus, and the l\mi)hoc\ tomas were few and not confined to any 

 particular group o organs or tissues. In Flock D the greatest numbers of neuro- 

 lymphomas were e(|ually divided between the celiac, sciatic, and brachial plexus, 

 and the largest numbers of hmphoc\tomas were about ecjualh divided between 

 the ovar\' aiifl muscles of the legs and wings. 



