26 MASS. EXPERIMENT STATION BULLETIN 308 



All of the hinls in I'"l()e-k K suffering from neuroKinphoniatosis conii)lirate<l 

 with Kniphocytoiiiatosis, as shown in Table 7, Group 5, had anemia, as indicated 

 b\ the low red blood counts and hemoglobin determinations. The white blood 

 cells of the birds were high, except in No. 83. The differential counts indicate 

 that bird No. 84 had leukocytosis, while Nos. 85, 86, and 87 had both leukoc\ tosis 

 and lymphoc\ tosis. At necropsy- all of the birds showed lesions of neurohnipho- 

 matosis and hmphocytomatosis. The neurolymphomas were confined to the 

 sciatic nerves and the lymphoc>tomas to the adjacent kidney tissues in birds 

 Nos. 83, 85, 86, and 87. In No. 84 general metastasis had apparenth- taken 

 place, for the left brachial plexus, liver, spleen, intestines, kidneys, proventricuius, 

 lungs, and muscles adjacent to the left brachial plexus were involved in tumor 

 formations. Histological sections indicated that these tumors were all lym- 

 phocytomas. 



Four cases of myeloleukosis were found in F~lock E (Group 6). The most 

 characteristic lesions found in birds Nos. Ill and 112 were chloromas. The 

 neoplasm in No. Ill had apparenth- originated in the li\er and had metastasized 

 to the muscles of the left breast. In bird No. 1 12 the m\ eloc>toma was general- 

 ized and appeared in the liver, spleen, heart, and left thyroid gland. Myeloblasts 

 and myeloc\tes were found in the blood of all four birds. Fresh myeloc> tes gave 

 positive oxydase tests. Birds Nos. 113 and 114 did not show characteristic 

 lesions of myeloleukosis on gross examination. But histological examination of 

 tissues from the liver of No. 113 showed myelocytes in the blood of the arteries, 

 sinuses, and capillary spaces. The kidneys were inflamed and swollen, and 

 neoplastic cells were demonstrated in the interstitial tissues surrounding the 

 glomeruli and tubules. The spleen was swollen and the tissues selected from it 

 indicated that a generalized infiltration was taking place in this organ. The 

 mucosa and muscular walls of the intestine were inflamed, but myelocytes were 

 not found in the tissues selected from them. The th\roid glands and \'agus 

 nerves were normal to gross inspection, although myelocytes were found in the 

 blood of arteries and capillaries leading into them. One of the thymus glands 

 showed a diffuse infiltration of myeloc\tes on histological e.xamination. All of 

 the tissues selected from bird No. 114 for microscopical study were normal, 

 except the bone marrow. This was inflamed, devoid of fat, low in eosinophilic 

 leukocytes, and showed evidence of calcification. 



One case of hmphocytomatosis complicated by myeloleukosis was found in 

 Flock E, and this was in pullet No. 115. At necropsy hmphoc\tomas were 

 found in\()h ing the li\"er, spleen, and mesenteries. Reference to Table 7, Group 

 7, shows that the eosinophilic m\eloc\te and the small hniphoc\te predominated 

 in the blood of this bird. 



Only one complication of neurolymphomatosis and coccidiosis was found in 

 this study and that was in Flock E. The hematology of this bird (Table 7, 

 Group 8) shows anemia, eosinophilia. and lymi)hoc\'tosis as prominent s\'mi)tunis 

 of this complication. 



The Hematology of Healthy Birds 



Fifteen healthy birds were examined hcmatologiralh for comparison with the 

 results of those in diseased conditions. A stud\ of Table 8 shows considerable 

 fluctuation not onh- in difTerent birds but in the same bird at different periods. 

 While the examination of the blood is of considerable \alue in the diagnosis and 

 difTcrcnt iation of the \arious forms of leukemia, it is not of nuich help in the 



