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in great numbers in the blood — the Spirochseta Obermeieri — 

 closely resembling the innocuous Spirochseta Cohnii or plicatilis 

 found in the mucus of the teeth. During the intervals between 

 the febrile attacks none of these organisms can be detected 

 in the blood. Outside the body they show active movements 

 at a temperature of 60" or 70", become languid at blood heat 

 and die at fever heat. The pyrexia therefore of the patient 

 is supposed to destroy the organism, which then breaks up into 

 a number of minute granules, some of which may constitute 

 the spores from which fresh crops of the organism may de- 

 velope. If blood containing spirochsetse is taken from a patient 

 during the stage of pyrexia and human beings or monkeys 

 inoculated with it, the disease can be reproduced, but not by 

 blood taken during the intervals between the febrile attacks. 

 Injections of the blood into other animals such as dogs, rabbits 

 and guinea-pigs were always without result. All attempts 

 to cultivate the organism outside the body have as yet been 

 unsuccessful, so that we really know very little of its history. 



Here again we have a disorder associated with a bacillus, the 

 organism disappearing and reappearing from the system and the 

 blood of the infected animal being intermittent in its power of 

 communicating the disease to other animals. 



Perhaps few disorders of the human frame have greater interest 

 attached to them than those associated with tubercle, and when 

 we remember that one-seventh on an average of the deaths of 

 human beings result from pulmonary tuberculosis, the importance 

 of any fresh light shed on this disorder, or the discovery of any 

 new fact can not easily be overestimated. The discovery, then, by 

 Koch in 1882 of a bacillus in the tubercular diseases of man and 

 animals has necessarily attracted a good deal of attention and led 



