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injected into the circulation of healthy animals, induce malaise 

 and all the signs of excessiv'e exhaustion." 



In convalescence from disease, too, how readily does the 

 evening temperature rise after any slight physical exertion ; and 

 at the commencement of typhoid fever perhaps nothing tends to 

 intensify the severity of the attack so much as physical fatigue. 

 It would seem in this case as if the soil for the cultivation of 

 the fever germ was materially enriched by the products of dis- 

 integration. 



In "fatigue fever" these products ai-e formed more rapidly 

 than they can be eliminated or neutralised. With rest the 

 febrile condition soon passes off, if the individual is otherwise 

 healthy. Now it appears to be the function of certain glands 

 besides the liver and kidneys, to get rid of the poisonous pro- 

 ducts resulting from the disintegration of the tissues, either by 

 neutralising or decomposing them or otherwise. If the action 

 of the glands is checked or modified either by disease or by 

 their removal, the poisonous material soon begins to exert its 

 specific effect on the system. We have recently been taught 

 that following upon disease or removal of the thyroid gland the 

 condition known as Myxoedema, with all its attendant phenomena, 

 arises. Again in disease of the suprarenal capsules "efiete 

 pigments and efiete proteids circulate in the blood ; the former 

 or their incomplete metabolites, producing pigmentation of skin 

 and mucous membrane, and appearing often in the urine as 

 urohsematoporphyrin ; the latter producing toxic effects, and 

 leading to further deterioration of the blood with its conse- 

 quences " (McMunn). If, then, from any cause due to glandular, 

 nervous, or other derangement in the system, these poisonous 

 substances are developed or not eliminated they will alter the 



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