.ss II. 1. 5. 1. QF SENSATION. 233 



ing or heat on making water; which begins at the external ex- 

 tremity of the urethra, to which the contagious matter is applied, 

 and where it has access to the air; which probably heightens its 

 acrimony. 



M. M. In this state of the venereal disease, one venesection, 

 with mild cathartics of senna and manna, with mucilage, as al- 

 mond emulsion, and gum arabic, taken for two or three weeks, 

 absolve the cure. Is camphor of use to relieve the ardor urinae? 

 Do balsams increase or lessen the heat of urine? Neutral salts 

 certainly increase the smarting in making water, by increasing 

 the acrimony of the urine. 



Can the discharge from the urethra be soon stopped by satur- 

 nine injections, or mercurial ones, or with solution of blue vitriol, 

 at first very dilute, and gradually made stronger? And at the same 

 time, lest the syphilis, or general disease, should supervene, the 

 patient might take a quarter of a grain of corrosive sublimate of 

 mercury twice a day, as directed below? 



There is a curious paper by Mr. Addington, of West Bromage, 

 in the Contributions of Medical Knowledge, published by Dr. 

 Beddoes, on the cure of gonorrhoea virulenta, by large doses of 

 corrosive sublimate of mercury, hydrargyrus muriatus. Three 

 grains of corrosive sublimate of mercury are dissolved in on'e ounce 

 of rectified spirit of wine. Half of this mixture is taken undiluted 

 at going to bed; it produces a copious salivation for an hour and 

 a half, or longer, during which the patient spits a quart. Some 

 Glauber's salts are to be taken on the second day after this ope- 

 ration, and on the evening of that day he is to repeat the draught, 

 and the salts on the day but one following. And Mr. Addington 

 witnessed that three or four such doses frequently cured a vene- 

 real gonorrhoea in so short a time, without any disagreeable con- 

 sequence, and was informed that hundreds had been cured by it. 



The probable mode of action of this medicine is owing to" the 

 consent of parts between the throat and the urethra, of which 

 many instances are given in Class IV. 1.2. 7. on Hydrophobia. 

 Mr. Wright, an elderly surgeon in Derby, thirty years ago, as- 

 sured me, that he had frequently given half a drachm of corro- 

 sive sublimate as an emetic, without any inconvenience to the 

 patient; and that it was the famous emetic of a celebrated em- 

 pyric, and had been said to do wonders. 



Might not this dose of one grain and a half, dissolved in half 

 an ounce of rectified spirit, be given repeatedly, with prospect of 

 advantage, in hydrophobia? And perhaps, in an adapted strength 

 and quantity, in hydrocephalus? If in croup, peripneumonia 

 trachealis? 



VOL. ir. H h 



