THE MICROSCOPE IN PATHOLOGY. 



265 



In the giant cells, so called, the nuclei number ten to fifty 

 or more. Physiologically these occur in bone marrow, 

 where they are regarded as transformed osteoblasts, and 

 pathologically in granulation tissue and many tumors. 

 In soft, yielding tissues their form is roundish, but in 

 fibrous tissues the giant cells have peripheral processes 

 (Fig. 214). 



FIG. 214. 



FIG. 215. 



Giant cells, a. Roundish (Virchow). 6. With processes. From a muscular tumor 

 (Billruth). After RINDFLEISCH. 



RindfleLsch has pointed out a cell-formation in nucleus- 

 bearing protoplasm, where apparently free nuclei are im- 

 bedded in homogeneous substance, but 

 reagents show a differentiation of the 

 protoplasm, so that to each nucleus 

 belongs a small round cell. This is 

 different from giant cells, and occurs 

 in many sarcomata and cancers (Fig. 

 215). 



Most cells are capable of increase. 

 The movable and fixed cells of con- 

 nective tissue, young bone, and carti- 

 lage cells ; the youngest layers of epi- 

 thelial cells, either of the surface or 

 glandular; the nuclei of capillaries, of the sarcolemma, 



Nucleated protoplasm. 

 Fragment from a granula- 

 tion. 



