DEFECTIVE DEVELOPMENT OF THE HEART. 135 



of brain. Of this latter many examples might be 

 added, and I propose at another time to give more 

 examples of concurrent defects of heart and nerve- 

 centres. In some of these patients the heart was 

 specially examined, not on account of any signs of 

 heart-defect, but in the search for examples of con- 

 current congenital defects. (Edema was absent in 

 all these cases. Cyanosis was present in Cases 1 and 

 4, and absent in the other four cases of this group. 



GROUP II. 



CASES WITH EVIDENCE OF CONGENITAL HEART- 

 DEFECT, NOT ASSOCIATED WITH OTHER KNOWN 

 DEFORMITIES. 



Case 7. Heart-defect Cardiac hypertrophy- 

 No bruit Marked cyanosis Convulsions No 

 other defects. 



Case 8. Heart-defect No cyanosis Bruit in 

 pulmonary area No other defects. 



Case 9. Heart-defect Cyanosis Bulbous fingers 

 No other deformities. 



Case 10. Heart-defect Cyanosis No clubbing 

 of fingers or toes No other deformity. 



Case 11. Heart-defect Varying amount of- cya- 

 nosis No bruit No other deformities. 



Remarks on Groups I. and II. Of these eleven 

 cases of heart-defect no co-existing deformity was 

 found in five. Cyanosis was present* in six cases 

 out of the eleven ; and- it is noteworthy that of 

 these cyanotic cases the larger proportion were in 

 Group II., where no co-existing deformities were 



