CLASS II. i. 5. i. OF SENSATION. 233 



ing or heat on making water ; which begins at the external ex- 

 tremity of the urethra, to which the contagious matter is appli- 

 ed, and where it has accefs to the air , which probably height- 

 ens its acrimony. 



M. M. In this (late of the venereal difeafe, once venefecfHon, 

 with mild cathartics of fenna and manna, with mucilage, as al- 

 jnond emulfion, and gum arable, taken for two or three weeks, 

 abfolve the cure. Is camphor of ufe to relieve the ardor urinre ? 

 Do balfams increafe or leiTen the heat of urine ? Neutral falts 

 certainly increafe the fmarting in making water, by increafmg 

 the acrimony of the urine. 



Can the difcharge from the urethra be foon flopped by faturnine ' 

 injections, or mercurial ones, or with folution of blue vitriol, at 

 firft very dilute, and gradually made ftronger ? And at the fame 

 time, left the fyphilis, or general difeafe, mould fupervene, the 

 patient might take a quarter of a grain of corrofive fublimare of 

 mercury twice a day, as directed below ? 



There is a curious paper by Mr. Addington, of Weft Bromage, 

 In the Contributions of Medical Knowledge, publifhed by Dr. 

 Beddoes, on the cure of gonorrhoea virulenta, by large dofes of 

 corrofive fublimate of mercury, hydrargyrus muriatus. Three 

 grains of corrofive fublimate of mercury are diffolved in one ounce 

 of rectified fpirit of wine. Half of this mixture is taken undi- 

 luted at going to bed ; it produces a copious falivation for an 

 hour and a half, or longer, during which the patient fpits a 

 quart. Some Glauber's falts are to be taken on the fecond day 

 after this operation, and on the evening of that day he is to re- 

 peat the draught, and the falts on the day but one following. 

 And Mr. Addington witneffed that three or four fuch dofes fre- 

 quently cured a venereal gonorrhoea in fo ihort a time, without 

 any difagreeable confequence, and was informed that hundreds 

 had been cured by it. 



The probable mode of action of this medicine is owing to the 

 confent of parts between the throat and the urethra, of which 

 many inftances are given in Clafs IV. i. 2. 7. on Hydrophobia. 

 Mr. Wright, an elderly furgeon in Derby, thirty years ago, af- 

 fured me that he had frequently given half a drachm of corrofive 

 Sublimate as an emetic, without any inconvenience to the patient ; 

 and that it was the famous emetic of a celebrated empyric, and 

 had been faid to do wonders. 



Might not this dofe of one grain and a half, diffolved in half 

 an ounce of rectified fpirit, be given repeatedly, with profpett 

 of advantage, in Hydrophobia 1 ? And perhaps, in an adapted 

 flrength and quantity, in Hydrocephalus ? If in Croup, Perip- 

 aeumonia trachealis ? 



VOL. II. G G 2. Syphilis. 



