358 CHYLE, LYMPH, TRANSUDATES AND EXUDATES. 



mogenin and has also other actions besides bringing about a marked 

 increase in blood-pressure by the strong contraction of the muscles of 

 the periphery vessels; for instance, it can bring about glycosuria and 

 mydriabis. This body has been chemically investigated by several 

 experimenters such as v. FURTH, ABEL, TAKAMINE, ALDRICH, JOWETT, 

 PAULY, ABDERHALDEN and BERGELL, FRIEDMANN and STOLZ. 1 v. FURTH 

 calls it suprarenin, ABEL epinephrin, and TAKAMINE adrenalin. This 

 last name seems to be the most generally accepted one. 

 Adrenalin (suprarenin epinephrin), 



CH 



(HO)C C.CH(OH)CH 2 .NHCH 3 

 (HO)C CH 



The constitution of adrenalin has been essentially proven by FRIEDMANN^ 

 and he has shown the correctness of the above formula, which was 

 given by PAULY. The synthesis of adrenalin, which was first performed 

 by STOLZ, S is also in accordance with this formula. By the action of 

 methylamine upon chloracetopyrocatechin we obtain methylaminoaceto- 

 pyrocatechin : 



C 6 H 3 (OH) 2 .COCH 2 Cl-f NH 2 CH 3 -C 6 H 8 (OH) 2 .COCH 2 .NHCH 3 .HC1, 



which yields adrenalin on reduction. 



The synthetically prepared adrenalin is optically inactive d-Z-adrenalin, 

 while that from the adrenals is optically active /-adrenalin. FLACHER has 

 recently divided the racemic adrenalin into the two optically active 

 components, and the identity of the so-obtained synthetical adrenalin 

 with the natural has been shown by ABDERHALDEN and FR. MiJLLER. 4 

 These last investigators also found that the /-adrenalin had at least 15 

 times as strong an action upon the blood-pressure as the d-adrenalin, and 

 later ABDERHALDEN with THIES and SLAVU found that the /-adrenalin 

 had also in other respects a much stronger action than d-adrenalin. 



1 The literature on this subject may be found in v. Fiirth, Zeitschr. f . physiol. Chem., 

 23, 26, 29 and Wien. Sitzungsber. Math. Nat. Kl., 112, 1903. See also Abel, Zeitschr. 

 f. physiol. Chem., 28; Amer. Journ. of Physiol., 1899, and The Johns Hopkins Hospi- 

 tal Bull., No. 76 (1897), 90 and 91 (1898), 120 and 128 (1901), 131 and 132 (1902); 

 Ber. d. d. chem. Gesellsch., 36; Abel and Taveau, Journ. of Biol. Chem., 1, and Fried- 

 mann, Hofmeister's Beitrage, 6 and 8. 



* Hofmeister's Beitrage, 8. 



8 Ber. d. d. chem. Gesellsch., 37. 



4 Flacher, Zeitschr. f. physiol. Chem., 58; Abderhalden and Franz Miiller, ibid., 

 58; with Thies, ibid., 59; with Slavu, ibid., 59. 



