530 THE RELATION OF COLLOIDS AND LIPOIDS TO IMMUNITY 



has accumulated bearing evidence as to the value of the test as a diag- 

 nostic procedure, the method has not, however, come into general use. 



Ascoli and Izar especially have advocated the test in the diagnosis of 

 cancer. In 100 cases of malignant tumors, they obtained 93 positive 

 reactions; in 103 cases of other diseases they obtained only one positive 

 reaction. Tedesko, Stabilini, Leitch, Kelling, and others have reported 

 favorably upon the practical value of the test in the diagnosis of cancer. 

 Burmeister 1 has found that a negative reaction has some value in 

 excluding cancer, and is of more value in arriving at a diagnosis than a 

 positive reaction, i. e., it has a higher negative than a positive value. 



The test has also been used in the diagnosis of typhoid fever, para- 

 typhoid fever, syphilis, tuberculosis (positive only in active cases) 

 echinococcus disease, etc. Obviously, other methods of diagnosis, such 

 as the agglutination reaction and the Wassermann reaction, have super- 

 seded this test in practical diagnosis. The method possesses, however, 

 considerable theoretic interest and is worthy of further investigation. 



^ 1 Jour. Infect. Dis., 1913, 12, 459. 



