QE 



i 



8 CONTENTS 



PAGE 

 CHAPTER XXX. PASSIVE IMMUNIZATION. SERUMS IN THE PROPHYLAXIS AND 



TREATMENT OF DISEASE. SERUM THERAPY 73 



Definition, 733 Purposes of passive immunization, 734 Kinds of passive 

 immunity, 735 Indications for passive immunization, 736 Contraindications 

 to passive immunization, 738 Technic of subcutaneous inoculation, 740 

 Technic of intramuscular inoculation, 742 Technic of intravenous inoculation, 

 742 Technic of subdural inoculation, 746. Serum Treatment and Prophylaxis 

 of Diphtheria, 754. Serum Treatment and Prophylaxis of Tetanus, 772. Se- 

 rum Treatment and Prophylaxis of Dysentery, 782. Serum Treatment and 

 Prophylaxis of Hog Cholera, 784. Serum Treatment of Snake Bites, 786. 

 Serum Treatment and Prophylaxis of Hay-fever, 786. Serum Treatment and 

 Prophylaxis of Meningococcus Meningitis, 788. Serum Treatment of Influenzal 

 Meningitis, 802. Serum Treatment of Pneumococcus Meningitis, 804. Serum 

 Treatment of Other Localized Pneumococcus Infections, 807. Serum Treat- 

 ment of Lobar Pneumonia, 807. Serum Treatment of Streptococcus Infections, 

 813. Serum Treatment of Gonococcus Infections, 818. Serum Treatment of 

 Staphylococcus Infections, 819. Serum Treatment of Anthrax, 820. Serum 

 Treatment of Typhoid Fever, 821. Serum Treatment of Plague, 822. Serum 

 Treatment of Cholera, 823. Serum Treatment of Tuberculosis, 824. Treatment 

 of Infectious Diseases with Specific Serum of Convalescents and with Normal 

 Serum, 825. Serum Treatment of Scarlet Fever, 825. Serum Treatment of 

 Acute Anterior Poliomyelitis, 826. Serum Treatment of Pneumonia, 828. 



CHAPTER XXXI. SERUM THERAPY (continued) 829 



Normal Serum Therapy, 829 Serum treatment of hemorrhage, 829 ^Serum 

 treatment of the toxicoses of pregnancy, 833 Serum treatment of skin diseases, 

 834. Autoserum Therapy, 835 Autoserum treatment of skin diseases, 835 

 Autoserum treatment of acute infectious diseases, 835 Autoserum treatment 

 of syphilis (salvarsanized serum), 836 Autoserum treatment of tuberculosis 

 of serous membranes, 841 Autoserum treatment of non-tuberculous effusions, 

 843. 



CHAPTER XXXII. CHEMOTHERAPY 844 



Principles of Chemotherapy, 845 Organotropism and parasitotropism, 845 

 Chemoreceptors, 847 Drug "fastness," 849 Therapia magna sterilisans, 851. 

 Salvarsan and Neosalvarsan in the Treatment of Syphilis, 852 Historic, 852 

 Properties of salvarsan, 854 Toxicity of .salvarsan, 855 Properties of neo- 

 salvarsan, 856 Methods for preparing salvarsan for administration-, 857 

 Methods for preparing neosalvarsan for administration, 857 Administration of 

 salvarsan and neosalvarsan by intravenous injec^n, 858 Reactive manifesta- 

 tions, 867 By intramuscular injection, 875 By intraspinous injection, 876 

 Contraindications and precautions in salvarsan therapy, 878 Value of salvarsan 

 and neosalvarsan in the treatment of syphilis, 879. Salvarsan in the Treatment 

 of Non-syphilitic Diseases, 880. Chemotherapy in Bacterial Diseases, 881. 

 Chemotherapy in Malignant Diseases, 887. 



PART V 

 EXPERIMENTAL INFECTION AND IMMUNITY 



Introductory, 890 Methods, 890 The Student, 890 Records, 891 Animal 



Experiments and Autopsies, 891. 



EXERCISE 1. Active Immunization of Animals, 891. 



Experiment 1, Production of Agglutinins, .Bacteriolysins and Opsonins, 891 

 Experiment 2, Production of Precipitins, 892 Experiment 3, Production of 

 Hemolysins, 892 Experiment 4, Production of Cytotoxin, 892. 



EXERCISE 2. Infection, 892. 



Experiment 5, Experimental Pneumonia, 892. 



EXERCISE 3. Toxins, 893. 



Experiment 6, Diphtheria Toxin, 893 Experiment 7, Method of Testing the 

 Virulence and Toxicity of Diphtheria Bacilli, 894 Experiment 8, Tetanus Toxin 

 (in vivo}, 895 Experiment 9, Tetanus Toxin (in vitro), 895. 



