382 BACTERIOLYSINS 



relatively slight, and tends to strengthen Metchnikoff's views regarding 

 the close relationship of the bacteriolysins to leukocytic products and 

 phagocytosis. While extracellular lysis can occur in the absence of 

 cells, especially in vitro, yet in the administration of antibacterial serums 

 the activities of the leukocytes are much in evidence, extracellular lysis 

 or bacteriolysis proper being rather subsidiary to intracellular lysis or 

 phagocytosis. 



The preparation and methods of standardization of antibacterial 

 serums are given in the chapter on Passive Immunization. Most effort 

 in this direction has been expended on the preparation of antiserums for 

 the treatment of meningococcic, streptococcic, pneumococcic, and 

 gonococcic infections, and the greatest success has been attained with 

 the various antimeningococcic serums. 



