710 ACTIVE IMMUNIZATION 



ler, 1 Manning, 2 Cooke, 3 Wood, 4 Goodale, 5 and Kitchens and Brown 6 

 indicate that the vaccine treatment of hay-fever, and particularly the 

 autumnal variety, is frequently successful and worthy of trial not only 

 prophylactically but also during an attack. My own experience has 

 been limited to 7 cases of the autumnal type due to rag-weed sensiti- 

 zation ; 4 of these persons were greatly benefited, 1 was not aided at all, 

 and 2 have been apparently cured for a period of about two years. 



Bronchitis. Allen speaks very highly of the value of autogenous 

 vaccines in the treatment of acute and chronic bronchitis and broncho- 

 pneumonia of children. Various microorganisms are found in the se- 

 cretions, and the vaccines used are generally mixed. The usual thera- 

 peutic measures are employed simultaneously. It is claimed that vac- 

 cines lessen the discomfort and hasten recovery. Recently I have ob- 

 served very good results in the treatment of a number of cases of chronic 

 bronchitis uncomplicated by bronchiectasis, and believe that an au- 

 togenous vaccine prepared under proper conditions forms a valuable 

 adjuvant to treatment. 



Pertussis. A hemophilic bacillus closely resembling the influenza 

 bacillus has been ascribed by Bordet and Wollstein as the cause of pertus- 

 sis. Several investigators who have used a stock vaccine of the per- 

 tussis bacillus claim that, used in small and appropriate doses, the 

 severity of the paroxysms of coughing is lessened, and the whole course 

 of the infection shortened; besides this, they assert, it decreases the 

 danger of a complicating bronchopneumonia. When the disease is 

 unusually severe and the prognosis is bad, a vaccine may be administered 

 in doses of 25,000,000 if the patient is over four years of age. The 

 pneumococcus and Bacillus influenzse are frequently associated, and a 

 mixed vaccine of these microorganisms may be of special aid in the later 

 stages of the disease. The usual remedial measures should be employed 

 while vaccines are being tried. The reports of Bamberger 7 and Graham 8 

 indicate that the administration of a vaccine may be of value in lessening 

 the severity of the disease. I have treated 6 cases with indefinite 

 results; in 2 an .autogenous vaccine was employed and a stock vaccine in 

 the remainder. A stock vaccine has been advocated for purposes of 

 prophylactic immunization, especially in institutions, where pertussis 

 among children claims a high mortality. 



1 Illinois Med. Jour., 1914, xxiv, 120. 2 Jour. Amer. Med. Assoc., 1915, Ixiv, 655. 

 3 Laryngoscope, 1915, xxv, 108. 4 Chicago Med. Rec., 1915, xxxvii, 453 . 



5 Boston Med. and Surg. Jour., 1915, clxxiii, 42. 



6 Jour. Lab. and Clin. Med., 1916, 1, 457. (Excellent review of the literature.) 



7 Amer. Jour. Dis. Children, 1913, v, 33. 8 Amer. Jour. Dis. Children, 1912, iii, 41. 



