34 N. H. AGR. EXPERIMENT STATION. [Bulletin 183 



On the other hand, the records of pigs Nos. 55 to 60 show no fatal 

 effects with doses of 2 and 3 units, continued thru 40 days. Pig 

 No. 62 and pig No. 64 succeeded in withstanding 5 units continued 

 thru a period of 40 days. 



On the whole, this table, as compared with the preceding two,- 

 rather clearly indicates that with guinea pigs the administration 

 of arsenic in the form of white arsenic, AS2O3, will cause fatal 

 poisoning at about 1/2 or 2/3 the dosage necessary for fatal 

 results when the arsenic is administered in the form of lead 

 arsenate. 



Summarizing, it would appear that the two propositions offered 

 at the beginning of this set of experiments may be answered as 

 follows : 



(1) So far as our experiments with guinea pigs may be relied 

 on, the results indicate that five or even ten times the average 

 maximum per apple found in our analyses could not be expected 

 io constitute a dangerous single dose for a human being. It 

 is quite true that a guinea pig may be less susceptible to this 

 poison than is a human being. But the weight of a guinea pig is 

 ■only about 1/100 of that of an adult human being. Even if the 

 guinea pig is less susceptible, we should not expect any such ratio 

 as 1 to 100. Therefore, since guinea pigs can ingest daily, with- 

 out serious poisoning, amounts of arsenate of lead equal to the 

 average maximum found on 6 apples, we should not expect serious 

 or fatal results to follow the daily ingestion of an equal amount by 

 an adult person. 



(2) So far as the guinea pigs fed in these experiments are con- 

 cerned, it is evident that arsenic administered in the form of 

 white arsenic will cause fatal poisoning in about one-half or two- 

 thirds the dosage required with arsenic administered in the form 

 of lead arsenate. If this is true, as would seem definitely indi- 

 cated, then the standards quoted in authorities for computing 

 dangerous or fatal doses of arsenic, being based on administra- 

 tion of the poison in the form of white arsenic or Fowler's solu- 

 tion, may be assumed as quite safe in estimating the danger or 

 safety of arsenic in residues of arsenate of lead. 



