448 INFECTION AND IMMUNITY. 



mals. The extract is administered by mouth. Jez 

 justifies this method, from the fact that the lym- 

 phoid organs have been shown to form typhoid 

 antibodies (Wassermann). From the clinics of 

 Eichorst and others favorable reports concerning 

 the remedy have been published. It has had no 

 extensive use. The preparation is made by the 

 Serum Institute of Berne and is expensive. The 

 suggestion of Fraenkel, that typhoid patients be 

 treated by subcutaneous injections of small quan- 

 tities of killed typhoid bacilli in order to hasten 

 the formation of antibodies has been kept alive 

 through the "typhoin" of Petruschky, but has not 

 had practical trial. Of a similar nature is the sug- 

 gestion of Eichardson, that the filtrates of typhoid 

 cultures be injected. Eichardson reports unsatis- 

 factory results with various preparations of typhoid 

 bacilli, including the non-toxic split products of 

 Vaughan. 



Anders has concluded from his results following 

 the injections of killed typhoid bacilli, that the 

 procedure is of value only in cases of relapse and 

 in bacillus-carriers in order to rid the person of 

 the bacilli. Doses of from 25 to 50 million bacilli 

 were used and the injections were repeated every 

 three days. 



The principles and technic of the agglutination 

 test were described in Part I. The serum 

 commonly becomes agglutinating on from the 

 seventh to the tenth day, rarely as early as the 

 second or third, and as late as from the twentieth 

 to the fortieth day. The power is highest during 

 convalescence, when it may agglutinate in dilu- 

 tions as high as 1 to 5,000 or higher, and from 

 that time sinks gradually. An agglutinating 



