ACTINOHYCOSIS. 629 



after the injection, reaches its maximum (from 40 

 to 42 C.) in from six to eight hours later, where 

 it remains for a few hours, then gradually sinks, 

 only to recur on the second day ; 2, an edematous 

 and inflammatory tumor at the point of injection, 

 which begins in from six to eight hours, and runs 

 its course in from three to eight days, ending in 

 resorption (Wladimiroff). Veterinarians gener- 

 ally agree that mallein is a valuable diagnostic 

 agent. Mallein also has been used in the treatment 

 of glanders, but with rather doubtful results. 



Bacteriologic diagnosis is accomplished by culti- 

 vating the bacilli from the abscess or secretions and 

 testing the virulence of the culture by animal ex- 

 periments (guinea-pig) . 



IV. RHINOSCLEROMA. 



(See page 572.) 



V. ACTINOMYCOSIS. 



Actinomycosis is a chronic infectious disease of 

 man and animals, the lesions of which present, 

 characteristically, a central mass of purulent and 

 necrotic material containing colonies of "ray 

 fungi," about or through which is disposed an 

 abundant growth of granulation or fibrous tissue. 

 In young or rapidly progressing lesions the amount 

 of purulent material is large, while in older lesions 

 well formed connective tissue is more conspicuous. 

 The disease prevails especially among cattle, al- 

 though it is met occasionally in the horse, hog, 

 sheep, dog, cat and other animals ; man is infected 

 not infrequently. 



Although fungous threads had been found in 

 diseases resembling actinomycosis in 1845 and 



