652 INFECTION AND IMMUNITY. 



the course of development and healing of the 

 lesion is more rapid. 



Apes with tertiary syphilis react (according to 

 Finger) to inoculation with syphilitic material, 

 with the formation of tertiary lesions. 



Finger conceives of the process of immunity in 

 syphilis as similar to the phenomenon of allergy 

 of V. Pirquet. That is in a variation in the capa- 

 bility of reaction without the establishment of 

 non-susceptibility. Second infections with syphilis 

 have also been observed clinically. 



The serum reaction is discussed fully in the 

 therapy, chapter on complement deviation. 



The efficiency which is promised by the recent 

 preparation of Ehrlich, known as salversan, leaves 

 but little to be desired as a therapeutic agent. The 

 lack of production of immunity also renders the 

 possibility of a curative serum very doubtful. 



III. FRAMBESIA. 



Frambesia or yaws is a tropical disease found 

 in both hemispheres. Castellani found a spirillum 

 associated with the lesions which corresponds mor- 

 phologically with the Spirochceta pallida. Owing 

 to this similarity in the organisms, and to the 

 fact that yaws resembles syphilis clinically, the 

 two have been considered as different forms of the 

 same disease. Castellani,, however, finds that in 

 the complement deviation reaction neither anti- 

 gen nor antibody can be used interchangeably. He 

 considers the two spirochetes as distinct from each 

 other and names the spirochete of yaws, Spiro- 

 chceta pertenuis. Transmission occurs by direct 

 contact and probably also by means of flies. 



