TRTPANO80MIA8I8. 673 



TRYPANOSOMIASIS IN MAN. 



Nepveu in 1898 first found trypanosomes in 

 the blood of man in Algiers in eight cases. His ob- Fever. 

 servations were passed over temporarily. The para- 

 site bears his name (T. nepveui). Again in 1901 

 Forde discovered similar parasites in Western 

 Africa (Gambia), and since that time a number 

 of cases of "Gambian fever" or trypanosomatic 

 fever in man have been imported. In this in- 

 stance the parasite was called T. gambiense by But- 

 ton and T. liominis by Manson. The disease is 

 said to follow the bite of a tsetse-fly (Glossina 

 palpalis), at least in some instances. The tissues 

 around the bite become inflamed and in from a 

 few days to two weeks recurring attacks of fever 

 set in, and a patchy and ringed erythematous erup- 

 tion appears on the skin. Forde gives as the 

 chief clinical findings in his case: (1) the irregular 

 intermittent temperature; (2) the edematous con- 

 dition of the face and lower extremities; (3) the 

 rapid and variable pulse and respiration, unac- 

 companied by any evident cause; (4) loss of 

 weight, with marked debility, wasting and lassi- 

 tude; (5) the persistence of these symptoms and 

 their resistance to treatment. The parasites are 

 most numerous in the blood at the time of the 

 febrile attacks. Recovery has not been reported. 



Sleeping sickness has been endemic in certain sleeping 



Sickness 



districts of Africa for a long time, and, although 

 confined to a very limited district at one time, it ap- 

 pears now to have extended to distant parts. Speak- 

 ing of trypanosomatic fever and sleeping sickness 

 collectively, Ruata says that while originally con- 

 fined to a small district in Western Africa between 



