REFLEX ACTION 



499 



THE 



ACTION OF 

 STRYCHNINE 



AND OF 

 CHLOROFORM 



The conver- 

 sion, by strych- 

 nine, of central 

 inhibition into 

 excitation, and 

 that of excitation 

 into inhibition by 

 chloroform, were 

 described above 

 (page 428). 



As we shall 

 see in the next 

 chapter, Magnus 

 has shown that 

 the extensor tonus 

 of the muscles of 



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" to develop rhythm of discharge there must be an approximation to the all-or- 

 none law." 



Graham Brown 

 (1912, pp. 285-286) 

 states that the 

 phenomena observed 

 by him cannot be 

 accounted for either 

 by a "drainage" 

 theory, or by a 

 metabolic one, nor 

 again by the assump- 

 tion of a self-gener- 

 ated antagonistic 

 stimulus. He sug- 

 gests that the re- 

 spective centres of 

 the corresponding 

 muscles of the two 

 sides act recipro- 

 cally on each other, 

 the one in excitation 

 inhibiting the other, 

 although, as he ad- 

 mits, the nature of 

 the inhibitory pro- 

 cess is not explained 

 thereby. 



Further details 

 of this interest- 

 ing question will 

 be found in the 

 papers by Graham 

 Brown (1912), 

 Forbes (1912, 2) 

 and Sherrington 

 (1913, 1). Fig. 

 157 illustrates 

 the phenomenon 

 well. 



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