PROTEOSES AND PEPTONES. 135 



tyrosine and indol but abundant leucine and glycocoll, and about 39 

 per cent of the total nitrogen in a basic form. The protoproteose, 

 according to PICK, on the contrary yields considerable tyrosine and indol, 

 only little leucine but no glycocoll, and contains only about 25 per cent 

 basic nitrogen. FRIEDMANN, HART, and LEVENE have obtained very 

 similar results in regard to the quantity of basic nitrogen in the two-pro- 

 teoses, although LEVENE as well as ADLER l did not find the same results 

 as PICK in regard to the amounts of monamino-acids in the two proteoses. 

 The work of LEVENE, v. SLYKE and BIRCHARD 2 show, in many important 

 points, a decided contradiction to the statements of PICK and these 

 divergent results may possibly be explained by the fact that they were 

 not working with pure substances, but rather with mixtures. 



According to PICK the heteroproteose is also more resistant toward 

 tryptic digestion than the protoproteose, a behavior which coincides 

 with RUHNE'S view of a resistant atomic complex, an anti group, in the 

 protein bodies. KUHNE and CHITTENDEN S regularly obtained on the 

 tryptic digestion of heteroproteose a separation of so-called antialbumid, 

 a body which is attacked with great difficulty in tryptic digestion, but 

 which separates as a jelly-like mass and which is richer in carbon (57.5- 

 58.09 per cent), but poorer in nitrogen (12.61-13.94 per cent), than the 

 original protein. The occurrence of such resistant complexes in diges- 

 tion has also been repeatedly observed. 



This antialbumid later attracted increased interest, because as 

 first found by D ANILE WSKY and later other investigators have shown, 

 that solutions of rennin, gastric juice, pancreatic juice, and papain cause 

 a similar coagulum in not too dilute proteose solutions. These coagula, 

 called plasteines (coagulum by rennin) by SAWJALOW, and coaguloses 

 (coagulum by papain) by KiJRAjEFF, 4 are similar in many respects to 

 antialbumid, having a higher content of carbon (57-60 per cent) and 

 nitrogen (13-14.6 per cent). In other cases the quantity of carbon as 

 well as nitrogen is lower (LAWROW). 



We cannot for the present make any positive statement as to the 

 importance and mode of formation of the coaguloses or plasteins. It 



1 Hart, Zeitschr. f. physiol. Chem., 33; Pick, ibid., 28; Friedmann, ibid., 29; Levene, 

 Journ. of Biol. Chem., 1; R. Adler, Die Heteroalbumose und Protalbumose des Fibrins 

 Dissert. Leipzig, 1907. 



2 Journ. of Biol. Chem., 8 and 10. 



3 Zeitschr. f. Biol., 19 and 20. 



4 The works of Danilewsky and Okunew are cited and reviewed in the following 

 Sawjalow, Pfliiger's Arch., 85, and Centralbl. f. Physiol., 16; and Zeitschr. f. physiol. 

 Chem., 54; Lawrow and Salaskin, Zeitschr. f. physiol. Chem., 36; Lawrow, ibid., 51, 

 53, 56 and 60; Kurajeff, Hofmeister's Beitrage, 1 and 2; see also Sacharow, Biochem. 

 Centralbl., 1, 233; Levene and v. Slyke, Biochem. Zeitschr., 13. 



