SUGAR IN THE BLOOD. 329 



of the blood, plasma and blood-corpuscles may be ascertained. In the 

 table on page 328 are given analyses of the blood of various animals by 

 ABDERHALDEN * according to HOPPE-SEYLER'S and BUNGE'S methods. 

 The analyses of human blood by C. SCHMIDT 2 are older and were made 

 according to another method, hence the results for the weights of the 

 corpuscles are perhaps a little too high. All the results are in parts per 

 1000 parts of blood. 



The relation between blood-corpuscles and plasma may vary con- 

 siderably under different circumstances even in the same species of animal. 

 In animals, in most cases considerably more plasma is found, some- 

 times two-thirds of the weight of the blood. 3 For human blood ARRONET 

 has found 478.8 p. m. blood-corpuscles and 521.2 p.m. serum (in defibrinated 

 blood) as an average of nine determinations. SCHNEIDER 4 found 349.6 

 and 650.4 p. m. respectively in women. 



The sugar was considered as occurring only in the serum and not with 

 the blood-corpuscles. According to the investigations of RONA and 

 MICHAELIS the blood-corpuscles of the dog contain considerable amounts 

 of sugar; and the quantity of sugar in the blood, in the blood-corpuscles 

 as well as in the plasma, is increased in man with diabetes mellitus. 

 HoLLiNGER 5 also found that in man, with normal quantity of sugar 

 in the blood, the sugar was distributed almost equally between the 

 blood-corpuscles and the plasma. 



The amount of sugar in the blood-corpuscles, which was shown by 

 LEPINE and BOULUD before MICHAELIS and RONA, has been the sub- 

 ject of numerous investigations by BANG and his pupils, LYTTKENS and 

 SANDGREN on the one hand and by RONA, MICHAELIS, TAKAHASHI, 

 FRANK and others on the other hand 6 . The results of these investiga- 

 tions are so contradictory that it is hardly possible for the present to 

 draw any positive conclusions. It seems to follow from them, nevertheless, 

 that the dog blood-corpuscles always contain sugar, while for the corpuscles 

 of the rabbit and man the conditions are somewhat doubtful and may 

 be variable (FRANK and BRETSCHNEIDER) . According to LYTTKENS 

 and SANDGREN the blood-corpuscles of man contain as maximum 0.06 



1 Zeitschr. f. physiol. Chem., 23 and 25. 



2 Cited and in part recalculated from v. Gorup-Besanez, Lehrb. d. physiol Chem., 

 4. Aufl., 345. 



8 See Sacharjin in Hoppe-Seyler's Physiol. Chem., 447; Otto, Pfliiger's Arch., 

 35; Bunge, Zeitschr. f. Biol., 12; L. and M. Bleibtreu, Pfliiger's Arch., 61. 

 4 Arronet, Maly's Jahresber., 17; Schneider, Centralbl, f. Physiol., 5, 362. 



5 Rona and Michaelis, Bioch. Zeitschr. 16 and 18; Hollinger, ibid., 17. 



6 Lepine and Boulud, Bioch. Zeitschr., 32; Lyttkens and Sandgren, ibid., 26, 31, 

 36; Rona with Doblin, ibid., 31, with Michaelis, ibid., 37, with Takahashi, ibid., 30; 

 Takahashi, ibid., 37; E. Frank, Zeitschr. f. physiol. Chem., 70, with Bretschneider, 

 ibid., 71 and 76; see also Oppler, ibid., 64 and 75. 



