380 CHYLE, LYMPH, TRANSUDATES AND EXUDATES. 



between adrenalin and tyrosine, which also gives melanin with the sepia 

 enzyme, and indeed tyrosine has been considered as the probable mother- 

 substance of adrenalin (HALLE). The investigations of E WIN'S and 

 LAIDAW l to prove this last-mentioned possibility have not given any 

 support thereto. 



Besides the action of producing a rise in the blood-pressure, adrenalin 

 is also of special interest because, as first shown by BmM, 2 it also has a 

 glycosuric action. We will discuss the question of adrenalin glycosuria 

 and the relation which seems to exist between the internal secretions 

 of the thyroids, the adrenals and the pancreas, when we treat of the 

 formation of sugar and pancreas diabetes. We cannot here enter into 

 the question of the reciprocal action between the adrenals and the other 

 organs. 



The hypophysis or pituitary gland has been little studied from a chemical 

 standpoint. An extract of the gland shows, by its action, a certain similarity to an 

 extract of the adrenals in that it causes a rise in blood pressure and by causing a 

 dilation of the pupils of the frog's eye, Still no adrenalin could be detected in the 

 gland. Also no iodine occurs in the glands (WELLS, DENIS 3 ). 



The gland consists essentially of two parts, one an outside formation of vascular- 

 glandular epithelium and a lower nervous part the infundibular part. The out- 

 side part seems to have a relation to the growth of the tissues and skeleton and 

 acromegalie and gigantism are claimed by many investigators to be related to this 

 part. The infundibular part, on the contrary, contains the specific bodies which 

 raises the blood -pressure and stimulates the smooth muscles of the uterus and 

 upon the kidney secretion. The relation of the hypophysis to other endocrinic glands 

 is still very much disputed. 



1 Halle, Hofmeister's Beitrage 8; Ewins and Laidaw, Journ. of Physiol., 40. 



2 Deutsch. Arch, f . klin. Med., 91 and Pfluger's Arch., 90. 



3 H. G. Wells, Journ. of biol. Chem., 7; W. Denis, ibid., 9. 



