Til KM 1ST I: V Ol I II K 1'TOM A I N 1 



cliulinc, by treating glycerin mooochlorhydrine with tri- 

 mcthylaniine. This base, triinetliyl-glyceryl-ammonium 

 hydrate., has this structure: 



CIL01I 

 CIKHI 



N(CII 3 ) 3 01I. 



It would- seem that HANRIOT'S base might possibly be 

 identical with mytilotoxine, but u careful comparison made 

 by I5i:ii-:<;KU showed that it possesses no physiological action 

 and that its chemical relictions are entirely different. 



Mytilotoxine would, therefore, seem to possess the for- 

 mula, ( 1 II 15 NO. 2 , as originally given it by BRIEGER. From 

 the fact that on distillation with potassium hydrate it yields 

 trimethylamine, it follows that mytilotoxiue is a quarter- 

 nary base. He is inclined to regard it as a methyl deriva- 

 tive of betainc, which is so common in mussels, and repre- 

 sents it by formula No. 1. 



(1) (2) 



00,11 CH,OII 



m.cir, 



N(rH 3 ),< 



.011 N(cii 3 ) r oii 



No. 1, however, is C 6 H 15 N0 3 , instead of C 6 1I 15 N(),, as 

 above. The formula No. 2, (J 6 II 17 N(),, would represent 

 a derivative of choline or muscarinc, with only a slightly 

 higher percentage of hydrogen. 



The AUROCJILORIDK, C 6 II 13 NO. r nCl.AuCl 3 (Au- 41.6(> 

 l>er cent.), crystallizes in cubes. Its melting-point is 18'2. 



It is well to observe that BUIK<JKU has been unable to 

 obtain this base from mussels that were allowed to putrefy 

 for sixteen days. 



Physiological Action. According to KIMKCKIJ, mytilo- 

 toxine produces all the characteristic effects seen in mussel 



