ANTI-HJEMOLYSINS 



453 



in over excess, float free in the blood, and can, when they come in 

 contact with complements with haptophoric groups like those 

 which produced them, cap over these and thereby prevent their 

 union with amboceptors. The toxophoric group of the complement 

 plays no part in this mechanism. 



It is of interest in this connection to mention that Schiitze ( 5 ) 

 noticed that inactivated serum could, when injected into an animal, 

 produce anti-complement as readily as could normal serum, from 



FlG. 23. The Formation of Anti-hsemolysins. 



which Ehrlich and Morgenroth argue that heat destroys only the 

 toxophoric end of a complement, leaving the haptophoric intact. 

 In other words, a body like a toxoid (see p. 442, footnote) is formed. 

 This is called a complementoid (D in Fig. 23). 



Arrhenius( 8 ) has, however, recently brought forward evidence 

 which seems to indicate that the anti-body which is produced when 

 complements are injected into an animal is not strictly an anti- 

 complement but an anti-lysin. In other words, the anti-body thus 

 produced combines with the hsemolysin (i.e. amboceptor + comple- 



