472 



BIBLIOGRAPHY 



tions, &c., are employed to bring more blood to the part. Thus the 

 old methods of treatment are explained by the discovery of opsonin. 

 Vaccination is made into healthy subcutaneous tissues to excite the 

 production of the specific opsonin there (Wright). 



Neisser and Sachs have made the following striking discovery : 



(1) A rabbit is immunised against ox blood. The rabbit's serum 

 is thus made hsemolytic to ox and to sheep blood (S). This rabbit's 

 serum (A) on standing loses the complement. 



(2) Normal guinea-pig's serum (B) can complement the rabbit's 

 serum (A). 



(3) A rabbit is immunised against man's serum. The serum 

 (C) of this rabbit mixed with A and B has no effect in preventing 

 haemolysis of S. 



(4) A trace of human serum added to A, B, and C prevents 

 haemolysis of S. One-millionth of a cubic centimetre of human serum 

 can thus be identified ! Serum dried on linen for two months gives 

 the test. Ape's serum will only act in concentration of one-thousandth 

 of a cubic centimetre, so the test is most specific.- 



The proteid contained in 1 c.c. of serum on which the reaction 

 depends cannot weigh more than about '05 grin., thus -o^-.o-^j-.o-o-o rm - 

 of proteid can be detected. (Editor's Note.) 



BIBLIOGRAPHY 



1 S. Peskind, The American Journal 

 of Med. Science, vol. cxxvii. p. 1011. 



2 G. N. Steivart, Amer. Journ. of 

 Phys., vol. xi. p. 250. 



3 Landau, cf. Biochemisches, Cen- 

 tralbl., Bd. I. 692. 



4 Bordet, Annalesdel'institut Pasteur, 

 T. 9 (1895) ; T. 10 (1896) ; T. 12 (1898) ; 

 T. 13 (1899) ; T. 14 (1900); and T. 15 

 (1901). 



5 H. Sachs, Lubarsch Ostertag's Er- 

 gebnissen der path. Anat., vii. Jahr- 

 gang. 



6 Preston Kyes, Berl. Klin. Wochen- 

 schr., 1903, Nos. 42 and 43. 



7 A. Wassermann, Volkmann'sSamm- 

 lung Klinischr. Vortrage, Serie xii. Nr. 

 331 (1902). 



8 Svante Arrhenius, Vortrag gehalten 

 im Kaiserlichen Gesund Leitsamte zu 

 Berlin, December 22 (1903). 



9 Ehrlich u. Morgenroth, Berlin. Klin. 

 Wochenschr. (1899) Nos. 1 and 22; 

 (1900) Nos. 21 and 31 ; (1901) Nos. 10, 

 21, and 22. 



10 W. Buttoch and W. Hunter, Cen- 

 tralbl. f. Bakter. I. Abt. Bd. 28. 



11 W. H. Welch, Huxley Lecture, Bull, 

 of Johns Hopkins Hosp., vol. 13 (1902). 



12 Osborne and Mendel, Proc. Amer. 

 Phys. Soc., Amer. Journ. of Phys., vol. x. 

 No. 6. 



13 Metchniko/, (1) Annal. de 1'institut 

 Pasteur, T. 9 (1895) ; T. 13 (1899) ; T. 

 14 (1900). (2) L'Immunit.4 dans les 

 maladies infectieuses. Paris, Masson 

 et Cie. (1901). 



14 Nuttall, Journal of Hygiene, vol. 

 i. p. 367 (1902). 



15 Jtadzievsky, Ztsch. f. Hygiene, Bd. 

 xxxiv. S. 369 (1900); cf. We'lch. 



16 T. Sollmann, Amer. Journ. of 

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17 Wright and Douglas, Proc. of the 

 Boy. Soc. (1903), 72, p. 357 ; do. (1904), 

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18 Hektoen and Ruediger, The Journal 

 of Infectious Diseases, vol. 2, p. 128 

 (1905). 



19 Buttoch, The London Hospital 

 Gazette, vol. xi. No. 7 (1905). Prac- 

 titioner (Nov. 1905). 



20 Barratt, Proc. Koy. Soc. (1905). 



21 J. Craiv, Proc. Eoy. Soc. (1905). 



1 Papers 5, &c., have been freely used in the compilation of the present 

 article. 



