41 



By methods essentially similar, Koch demonstrated 

 the association of another form of septic infection 

 of mice, with a micrococcus species ; of septicaemia 

 in rabbits with a bacterium ; and of pyaemia (with me- 

 tastatic abscesses) in the latter animal with a micro- 

 coccus variety. Yet, although the fact of association 

 was amply demonstrated, there still remained the pos- 

 sibility of objection that the essential agent in the in- 

 fection was a soluble, unorgani/ed substance contained 

 in the putrid liquids and the infectious tissues used for 

 inoculation, the bacteria being the result and not the 

 cause. The final demonstration to the contrary, the 

 proof that these different effects could be induced by 

 inoculation with the respective bacterial varieties after 

 complete isolation from accompanying animal tissues by 

 cultivation upon solids, was not furnished at the time of 

 this publication by Koch, but has been subsequently com- 

 pletely established by Koch, Gaftky, and Loffler in the 

 laboratory of the German Health Bureau, for the bacilli 

 of mouse- and the bacteria of rabbit-septicaemia. The 

 extreme accuracy and critical supervision of manipula- 

 tions, the logical sequence of methods, and withal the 

 unpartisan candor and earnest desire for truth evident 

 throughout this work of Koch's, inspired at once a confi- 

 dence which has not as yet been diminished nor betrayed. 

 It is worthy of note that the infectious disease of mice de- 

 scribed by Koch as malignant oedema is identical in clin- 

 ical and pathological appearances with that which Pas- 

 teur ascribes to his " vibrio septique ; " while the pyaemia 

 of rabbits corresponds accurately with the purulent infec- 

 tion which, according to Pasteur, follows the injection of 

 his microbe of pus. These results, obtained quite inde- 

 pendently by two observers, using different methods, have 

 been confirmed not only by Gaffky and Loffler, but also 

 by Rosenberger in Wiirzburg, in a series of carefully per- 

 formed experiments. 



A review of the evidence already considered shows, 

 then, that infectious diseases, identical in clinical and 

 anatomical appearances with the various forms denom- 



