The internal organs as well as the cutaneous tubercles 

 of patients afflicted with leprosy contain a distinct bac- 

 terium the bacillus leprae. Attempts to induce the 

 disease in the lower animals by inoculation with the iso- 

 lated bacilli as well as with leprous tissue, have not as 

 yet been successful. 



Frisch, of Vienna, has found a characteristic short, 



-, 



Fig. 9. Skin excised, intra vitam, from a case ot erysipelas; micrococci in 

 lymph-vessel, x 700. (Koch.) 



thick bacillus in every case of rhinoscleroma (twelve in 

 number) which he has had opportunity to examine. 

 Pieces were excised from the nose or mouth intra vitam ; 

 the bacilli occur, like those of leprosy, in the large cells 

 characteristic of the tissue. Frisch cultivated these or- 

 ganisms on solid media, after Koch ; but was unsuc- 



