ACTION ON CIRCULATION AND RESPIRATION. 127 



The infusion used in tliis case was made by infusing 2 drachms of powdered 

 digitalis leaves in 4 ozs. of water, 



Exp. XI.— Nov. ?o, 1864.— At 10.12 a.m. I injected 4 milligrams of 

 digitaline, about xoth of a grain, suspended in about 30 minims of distilled water 

 into the subcutaneous cellular tissue of the lumbar region of a Skye terrier. 

 Three minutes after he began to lick the part, and when the injection was made, 

 showed signs of irritation. In 4f minutes he seemed a little confused, and 

 began to lick the corresponding part on the opposite side. In 5 minutes his 

 tongue began to loll out (which I have hardly ever observed in him before or 

 since), and he continued restless till 7^ minutes, when he lay down, his breathing 

 being rather hurried, and his tongue still out. In another minute he rose, and 

 sat apparently intently listening, and as there was no particular sound at the 

 time, I thought this probably indicated ringing in his ears. With the exception 

 of some restlessness he seemed well till 25 minutes after the injection, when he 

 sat down panting and lolling his tongue, as if he had had a smart run, though 

 he had made no particular exertion to account for this. Soon after he seemed 

 quite in his usual, and was none the worse. 



Exp. XII. — Dec. 12. — A mongrel dog had some blood drawn from one jugular 

 for examination, about the 6th, and on the 9th one of its carotids was exposed, 

 and the heemadynamometer applied under chloroform, but clots formed imme- 

 diately, and the experiment was abandoned. On the 12th the dog was very 

 weak. 



Afc 2.5' P.M., I began to inject i a grain (from memory) of digitaline in 

 water into the subcutaneous cellular tissue in the lumbar 

 region. 



2.12' Injection finished. The dog seemed uneasy and lay down. 



2.16' Till now he has been rising, turning round, and lying down again 

 constantly. He now seems unable to stand well — grumbles. 



2.17' 30 Up again, grumbles, shakes his head listlessly about, seems 

 uneasy. 



2.18' Seems inclined to vomit. 



2.19' Shakes his head and licks his foot. 



2.20' Paws his bed. 



2.21' Opens and shuts jaws. 



2.23' Sits up. The light is shining in his eyes, and his pupils are much 

 contracted. Seems livelier. Shakes his head and paws his bed. 

 I was then called away, and returned at 2.35'. 



2.35' Dog lying quite still, but there is a tremor all over and twitchings 

 of the subcutaneous muscle of limbs, causing the movement of 

 skin to be distinctly visible, but causing no movement of the 

 limb. Breathing slow and laboured. Eesi^irations are 8 in 

 65 seconds. 



2.43' Pulse 30 per minute, 2 or 3 beats coming close together during 

 inspiration and expiration, and then an interval of 4 seconds 

 between the beats, as well as one of exactly the same length 

 between the end of on»e expiration and the beginning of 

 another. 



