ACTION OF CONDURANGO ON FROGS. 341 



to be somewhat languid, and five days after tlie injection it was 

 dead. 



Ejypcriment II. — A strong frog was suspended by the fore 

 legs and two grains of solid extract were introduced under the 

 skin of the abdomen. Immediately afterwards the frog seemed 

 somewhat more restless than before, and drew up its legs more 

 quickly when they were touched. Its movements were per- 

 formed in the same way after the injection as before it. When 

 placed on a level surface it seemed quite unaffected by the 

 Condurango, and continued to be so for the next ten days 

 during which it was observed. 



Experiment III. — One grain of extract mixed with a few 

 drops of water was injected under the skin of the back of a 

 strong frog suspended in the same way as the other. Imme- 

 diately afterwards it became restless, and seemed also uneasy 

 when touched. Otherwise it remained unaftected, and no effect 

 of the Condurango could be observed during the next ten days. 



Ejcperiment 1 V. — Two grains of the extract mixed with a few 

 drops of water were injected under the skin of the back of a 

 frog suspended like the others. The result was the same as in 

 Experiment III. 



Experiment V. — Five grains of the extract were suspended in 

 water and injected under the skin of the back of a strong frog. 

 The frog was suspended by the head. It seemed somewhat 

 restless after the injection, but no other effect could be observed. 

 Next day it seemed in its normal condition, and on the third 

 day also. 



Experiment VI. — The same experiment as in V was repeated 

 with a like result. 



Experiment VII. — The same as in V and VI. No result was 

 observed at first. Next day the frog seemed weak, and when 

 laid on its back could not turn over so readily as the others. 

 It was a smaller frog than the others. On the third day it 

 seemed well. 



These experiments show that the extract of Condurango when 

 injected under the skin of frogs produces no effect even when 

 such a large dose as 5 grains is administered. 



The restlessness which is noted in those hung up was in all 



