350 



PHYSIOLOGICAL ACTION OF CONDURANGO. 



Uninjured Frogs. 



Frog I, Expt. XI 



Frog I, Expt. XII 

 „ XIII 



R. L. 



21i^ more 20 more 

 In the time after injection 

 -^ less 2f less 



-r'a more y\ more 



E. 



■I less 

 2 1 more 



-j^ more 

 24y*j more 

 3-/ij more 

 If 'more 



Frogs wliicli received Condnrango. 

 L. 



5^5 more 

 15^ more 



T5 less 

 29J more 



3^2 niore 



Sy'^jj more 



Frog II Expt. XI 

 III 



IV 

 II 

 II 

 II 



XII 



XIII 



XIY 



2 grs. solid extract 

 2 grs. in water 

 2 grs. „ 

 5 grs. „ 

 5 grs. „ 

 5 grs. „ 



In only one of these experiments (Experiment XII) does 

 any marked diminution of reflex excitability occur after the 

 injection of Condurango. Nearly as great a diminution is to be 

 observed in Experiment XI, Frog I, where nothing had been 

 injected, and it is therefore probable that the exceptional 

 diminution in Experiment XII as well as in Experiment XI, 

 Frog I, is to be ascribed to an individual peculiarity of the frog 

 and not to the action of the Condurango. 



In most of the other experiments we find a slight diminution 

 of reflex excitability, but it is very slight and might be due to 

 the exhaustion produced by the struggles of the animal after the 

 injection of the drug. 



Conclusions regarding the Effect of Condurango on Reflex Action. 



Unlike quinine Condurango has very little effect on reflex 

 action. A slight diminution of reflex excitability was observed 

 after the injection of the extract into frogs in doses of 2 or 5 

 grains, but the number of experiments is insufficient to show 

 whether or not this was due to the exhaustion produced by the 

 struggles of the frog. 



Effect of Condurango on Cireidation and Respiration. 



Experiment XV. — A cannula was placed in the trachea of a 

 rabbit and connected by india-rubber tubing with a T-tube, to 



