ACTION ON ARTERIOLES. 3oV 



These experiments show tliat Concluraiigo has no action on 

 the pressure of the blood when it is injected into the peri- 

 toneum in large doses. The diminished blood-pressure noticed 

 in some instances mioht be due to the animal's strentrth bein^' 

 diminished by its position on the board and the effects of the 

 operations. Its effect on the pulse and respiration is not con- 

 stant, the injection being sometimes followed by quickening 

 and sometimes by slowing, and moreover the results which 

 followed its injection into the jugular miglit in some degree be 

 due to the presence of fine particles in it having a mechanical 

 effect. 



The whole subject of the pulmonary circulation, the action of 

 drugs upon it and the effect which changes in it produces upon 

 other parts of the body, is at present very imperfectly known, 

 and it is therefore extremely difficult or impossible to say what 

 the effect of such fine particles as were contained in the solu- 

 tion of extract might be when they once enter the pulmonary 

 vessels. 



Tor the purpose of ascertaining whether Condurango had 

 any effect in contracting or dilating the arterioles and capil- 

 laries, the vagus was irritated so as to stop the heart, and the 

 rapidity with which the blood-pressure fell during the stoppage 

 of the heart before the injection was compared with that which 

 was found after it. 



Experiment XVIL Tracing II. 



Blood -pressure fell 38 mm. in ■^''jths of a second "i ... 



.Q 'c, I o^o^e iu]ection 



21 „ /.ths in one pulse wave J ^^^§™^^^- 

 „ „ 38 „ aVhs of a second i 



„ „ 18 „ iffths in one pulse wave J "^ 



These numbers show that with the instrument employed no 

 definite conclusion can be drawn regarding the state of contrac- 

 tion of the arterioles, but indicate that no extensive alteration 

 was produced in them by the Condurango. 



It may seem strange that I have not made any experiments 

 on the effect of Condurango on tissue change as indicated by 

 the amount of urea and salts in the urine more especially, as it 



