GENERAL ACTIONS. 459 



10. In cats arid clogs the symptoms are restlessness, nausea 

 succeeded by violent vomiting, spasmodic jerks of the limbs 

 during locomotion, quickened respiration, staggering gait, 

 inability to stand, and death generally during a convulsion 

 of an emprosthotonic character, apparently connected with 

 an attempt to vomit. Consciousness seems to be preserved to 

 the last. 



When injected subcutaneously, although it produces violent 

 vomiting, it never purges ; division of the vagi before its 

 administration lessens or prevents the vomiting usually 

 observed, as well as the other symptoms of distress ; and 

 in one instance a dose which would ordinarily have been 

 speedily fatal produced no apparent effect in an animal thus 

 operated on. 



11. When injected into the stomach of a cat it produces 

 violent vomiting and purging. Sometimes this is followed by 

 recovery, in other cases by loss of muscular power and death. 



12. Injection of atropia does not prevent death ; and although 

 in one case it prolonged life for two liours, in other instances it 

 seemed rather to accelerate a fatal issue. 



13. It causes the heart in frogs to pulsate more slowly; the 

 ventricle becomes irregularly contracted, leaving pouches over 

 the surface, and finally is arrested in systole ; the auricles con- 

 tract for some time longer 



14. In cats the ventricle also becomes irregularly contracted 

 before finally stopping. 



15. In frogs it causes no rise of the blood-pressure in the 

 aorta, but raises the oscillation of the mercurial column con- 

 nected with the vessel to three times its previous height. 



16. In cats and dogs moderate doses injected into the jugular 

 vein first raise the bluod-pressure without altering the rate of 

 cardiac pulsation or the extent of oscillation at each beat ; they 

 then slow the heart by stimulating the roots of the vagus. The 

 tension rises, notwithstanding the slowness of the heart's beats. 

 An additional dose paralyses the ends of the vagus in the heart, 

 and quickens its pulsations ; the pressure rises slightly. A 

 further dose again slows the heart by actiiig on its ganglionic 

 apparatus, and the beats sometimes fall as low as three per 



