SYMPTOMS PRODUCED. 487 



Voluntary muscles (rectus abdoniinis) also granular (well 

 marked, but not quite so much as the heart). 

 Bladder : muscular coat not degenerated. 

 Intestines : muscular coat not degenerated. 



Eemarks on Experiments I — III. 



Experiments I to III show the effects of the poison on cats 

 when administered in three decreasing doses. 



It will be seen that, durhig life, the most prominent 

 symptoms of a rapidly poisonous dose were in their order of 

 constancy : — 1, vomiting ; 2, respiratory difficulty ; 3, abnormal 

 muscular movements. 



After death the condition of the heart and great vessels and 

 of the lungs are most noteworthy. 



Vomiting. — This was a constant symptom in all the cats we 

 experimented on, unless they were placed under special circum- 

 stances. The vomit consisted, first, of whatever food might be 

 contained in the stomach, and then of a white frothy mucus. 

 On no occasion did it ever have the appearance of intestinal 

 (faecal) vomiting. 



In Experiment I no actual vomiting occurred. In this case 

 the stomach was found to be empty of food after death ; and 

 the absence of the symptoms in this case was doubtless due to 

 the rapid paralysis caused by the very large dose administered. 



Bespiratorij DiJJiadty. — This is a constant symptom, except 

 when very small doses are administered. 



On reference to Experiment I it will be seen that at one 

 time the respirations rose to 160 per minute. This, however, 

 was exceptional. From 40 to 60 respiratory movements per 

 minute is probably the avernge rate after administration of a 

 moderately poisonous dose. 



Abnormal Muscular Movements. — These are of two kinds ; 

 thus, immediately after the administration of any dose, large or 

 small, there is very generally produced a peculiar twitching of 

 the muscles of the limbs, especially of the hind legs. This is 

 especially seen when the animal is walking. 



When large, rapidly poisonous doses are administered 



