SYMPTOMS AFTER VAGOTOMY. 497 



Experiment XXIII. — March 6. 



General Symptoms after Injection, both Vagi having teen 

 jpreviously divided. 



A cat weighing 3 lbs. was chloroformed, and the vagi divided 

 in the neck. In 25 minutes after the operation it had recovered 

 from the effects of the anaesthetic. Its respirations were 18 per 

 minute. 3 c.c. of a concentrated alcoholic solution of alcoholic 

 extract of casca were injected subcutaneously. Five minutes 

 afterwards the cat had fallen over on its side. The respirations 

 were still regular, 16 per minute. During the next hour, with 

 one temporary disturbance, the animal remained quiet, still 

 breathing quietly and slowly, with no symptoms of sickness and 

 no dyspnoea. It remained on its side the whole time, except 

 when roused. It then staggered a few steps, and again lay 

 down. One hour after the first injection 2J c.c. more were 

 injected. For the next quarter of an hour the animal con- 

 tinued to breathe easily, but appeared weaker. At the end of 

 that time there were some very slight convulsive movements, 

 and then respiration ceased. On beginning artificial respiration 

 one or two gasping inspirations occurred, and then entirely 

 ceased 1 hour and 15 minutes after the first injection. On post 

 mortem examination the heart's cavities were found distended. 

 They did not contract on irritation or puncture. The lungs 

 were bright scarlet, and contained a moderate amount of blood. 

 The liver and kidneys were congested ; the stomach was pale ; 

 the brain was normal. 



Experiment XXIV.— April 28. 



This experiment was in most points an exact repetition of 

 Experiment XXIII, but the results were even more striking. 

 A well-nourished cat was chloroformed, and both vagi were 

 divided in the neck. When it had recovered from the chloro- 

 form a solution of '3 gramme of the alcoholic extract in 4 c.c. 

 of alcohol was injected subcutaneously. None of the ordinary 

 symptoms of poisoning by the drug were produced. There 

 was no dyspnoea and no vomiting, except at one time, an 

 hour and 15 minutes after the injection, when the . animal 



2 K 



