CONTENTS. xxv 



degeneration of muscles. Fatty infiltration. Intestines ; structure and 

 functions of the villi. Reabsorption and retention of the chyle. Liver; 

 intermediate interchange of matter by means of the biliary ducts. Fatty 

 liver. Fatty metamorphosis. Glands ; secretion of sebaceous matter and 

 milk (colostrum). Granule-cells and granule-globules. Inflammatory 

 globules. Arteries ; fatty usure and atheroma in them. Fatty debris. 



LECTUEE XVI. A MOKE PRECISE ACCOUNT OF FATTY 



METAMORPHOSIS 383 



Fatty degeneration of muscles. Fatty metamorphosis of the substance of 

 the heart. Formation of fat in the muscles in distortions. Corpus lu- 

 teum of the ovary. Fatty metamorphosis of pulmonary epithelium. 

 Yellow softening of the brain. Arcus senilis. Optical properties of 

 fattily degenerated tissues. Renal epithelium in Bright's disease. Succes- 

 sive stages (cloudy swelling, fatty metamorphosis, fatty detritus (debris), 

 atrophy). Inflammatory globules. Similarity of the result in inflamma- 

 tory and non-inflammatory changes. Atheromatous process in arteries. 

 Its relation to ossification. Inflammatory character of the process ; its 

 analogy with endocarditis. Formation of the atheromatous deposit. Ap- 

 pearance of cholestearine. Arterio-sclerosis. Endoarteritis. Calcifica- 

 tion and ossification of arteries. Mixed, active-passive processes. 



LECTURE XVII. AMYLOID DEGENERATION. INFLAMMA- 

 TION . . . . <,. . ... . . . 409 



Amyloid (lardaceous or waxy) degeneration. Different nature of amyloid 

 substances : concentric and laminated amyloid bodies (brain, prostate), 

 and amyloid degeneration properly so called. Its course. Commence- 

 ment of the affection in the minute, arteries. Waxy liver. Cartilage. 

 Dyscrasic (constitutional) character of the disease. Intestines. Kidneys: 

 the three forms of Bright's disease (amyloid degeneration, parenchyraa- 

 tous, and interstitial nephritis). Lymphatic glands. Functional disturb- 

 ances of the affected organs. Inflammation. The four cardinal symptoms 

 and their predominance in the different schools : the thermic and vascu- 

 lar theory ; the neuro-pathologists, exudations. Inflammatory stimuli. 

 Lesion of function. Exudation as a consequence of the activity of the 

 tissues ; mucus and fibrine. Inflammation as a complex irritative pro- 

 cess. Parenchymatous and exudative (secretory) form. 



LECTURE XVIII. NORMAL AND PATHOLOGICAL NEW 

 FORMATION 438 



The theory of continuous development in opposition to the blastema and 

 exudation theory Connective tissue and its equivalents as the most 

 general germ-store of new formations. Correspondence between embry- 

 onic and pathological new formation. Cell-division as the most general 

 starting-point of new-formations. Endogenous formation. Physalides. 

 Brood-cavities. Different tendencies of new-formations. Hyperplasia, 

 direct and indirect. Heteroplasia. Pathological formative cells. Differ- 

 ence in their size and in the time required for their full development- 

 Description of the development of bone as a mf del- formation. Differ- 



