346 LECTURE XIV. 



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that about such a divided nucleolus the finger-biscuit-like 

 constriction, and afterwards the real division, of the nu- 



cleus takes place, as we have already seen in colourless 

 blood- and pus-corpuscles (Figs. 11, A, b; 56, 63). Here 

 we manifestly have to deal with something essentially 

 different from what we had before. In the simple hy- 

 pertrophy consequent upon nutritive irritation, the nu- 

 cleus may remain quite intact ; here, on the other hand, 

 we frequently see that the contents display a relatively 

 slight amount of change, the utmost being that the cells 

 become larger, whence we infer that a quantity of new 

 material has been taken up into them. 



In many cases the changes are limited to this series of 

 transformations, of which the division of the nucleus must 

 be regarded as the conclusion. This may be repeated, 

 so that three, four or more nuclei arise (Fig. 15, b, c, d). 

 Thus it comes to pass that we sometimes find cells not 

 merely in pathological conditions, but also not unfre- 

 quently where the development is altogether normal 

 which contain twenty to thirty nuclei or more. Recently 

 in the marrow of bones, especially in young children, 

 cells have been observed, where the entire structure is 



Fig. 103. Cells from a melanotic tumour of the parotid gland extirpated in 1851 

 by Herr Textor. A. Free cells with division of the nucleoli and nuclei. B. Net- 

 work of connective tissue-corpuscles with division of their nuclei. 300 diameters. 



