LECTURE XIV. 



FIG. 105. 



resemblance to those plaques a plusieurs noyaux which 

 Robin has described in the marrow of bones. This is 

 something quite peculiar which looks extremely like the 

 commencement of a real new- 

 formation, only that new-forma- 

 tions in the ordinary sense of 

 the word are not limited to sin- 

 gle cell-constituents. Besides 

 we must bear in mind this very 

 important fact, that exactly the 

 same limitation takes place in the 

 earliest embryonic development 

 of muscle, in the course of the 

 first growth of the primitive 

 muscular fasciculi. For this is 

 the manner in which muscle 

 originally grows. If a growing 

 muscle be watched, the same 

 division of the nuclei is wit- 

 nessed, and after groups and 



rows of nuclei have arisen in it, they are, in the course 

 of growth, gradually thrust farther and farther asunder 

 by the continual increase of the intermediate sarcous sub- 

 stance. Now although a growth in length has not as yet 

 been demonstrated with certainty in a pathologically irri- 

 tated muscle I say demonstrated, because there really 

 is a probability that something of the kind may yet be 

 proved to be the case we must still hold the perfect 

 analogy of morbid irritative processes with the natural 

 ones of growth to be a well-ascertained fact. For the 

 formative act of real growth begins with a multiplication 



Fig. 105. Division of nuclei in primitive muscular fasciculi from the immediate 

 neighbourhood of a cancerous tumour in the thigh. At A a primitive fasciculus, 

 the transverse striation of which is not represented all the way down, with its na- 

 tural, spindle-shaped extremity f, and incipient multiplication of the nuclei. B. 

 Strongly marked proliferation of nuclei, 300 diameters. 



